Sanderson P W, Lis L J, Quinn P J, Williams W P
Biomolecular Sciences Division, King's College London, U.K.
Biochim Biophys Acta. 1991 Aug 5;1067(1):43-50. doi: 10.1016/0005-2736(91)90024-3.
The phase behaviour of L-alpha-1-palmitoyl-2-oleoyl-phosphatidylethanolamine (POPE) was examined in aqueous dispersions containing a range of sodium salts. The phase properties of the lipid exhibited a graded response to the presence of simple anions analogous to that of the Hofmeister series encountered in the study of the solution properties of proteins. Salts early in the series (such as Na2SO4 and NaCl) gave rise to substantial decreases in the temperature (Th) of the transition from the lamellar liquid-crystal to inverted hexagonal phase (L alpha----HII) and small increases in the temperature (Tm) of the transition from the lamellar gel to lamellar liquid-crystal phase (L beta----L alpha). Salts towards the end of this series (such as NaI and NaSCN) led to increases in Th and decreases in Tm. Similar effects were seen in lipid dispersions containing a series of non-ionic co-solutes. In both cases, the relative efficiency of perturbation of the lipid phase properties reflected the relative ability of the anion or co-solute to influence the structure of the bulk water. X-ray diffraction measurements indicated that these effects were probably mediated through the ability of the co-solutes to bring about changes in the extent of the lipid/water interface.
在含有一系列钠盐的水性分散体中研究了L-α-1-棕榈酰-2-油酰基磷脂酰乙醇胺（POPE）的相行为。脂质的相性质对简单阴离子的存在表现出分级响应，类似于在蛋白质溶液性质研究中遇到的霍夫迈斯特系列。该系列早期的盐（如Na2SO4和NaCl）导致从层状液晶到反相六方相转变的温度（Th）大幅降低，以及从层状凝胶到层状液晶相转变的温度（Tm）小幅升高。该系列末尾的盐（如NaI和NaSCN）导致Th升高和Tm降低。在含有一系列非离子共溶质的脂质分散体中也观察到类似的效果。在这两种情况下，脂质相性质扰动的相对效率反映了阴离子或共溶质影响大量水结构的相对能力。X射线衍射测量表明，这些效应可能是通过共溶质引起脂质/水界面范围变化的能力介导的。
