Cano-Europa Edgar, Pérez-Severiano Francisca, Vergara Paula, Ortiz-Butrón Rocío, Ríos Camilo, Segovia José, Pacheco-Rosado Jorge
Departamento de Fisiología "Mauricio Russek", Escuela Nacional de Ciencias Biológicas, IPN, Prol. Carpio y Plan de Ayala, s/n, cp. 11340 Mexico City, Mexico.
Metab Brain Dis. 2008 Sep;23(3):275-87. doi: 10.1007/s11011-008-9099-0. Epub 2008 Aug 6.
The effects of hypothyroidism on lipid peroxidation (LP), reactive oxygen species (ROS), and nitric oxide synthase (NOS), levels and expression, in rat brain were examined. Hypothyroidism was induced by administering methimazole in drinking water (60 mg/kg/day). In striatum, motor cortex and cerebellum of hypothyroid rats LP was not modified, whereas LP and ROS increased in amygdala and hippocampus of hypothyroid rats at the third week of treatment with methimazole as compared to euthyroid group values. Regarding NOS participation, only hippocampal constitutive-NOS activity was increased, accompanied by an augmentation in nNOS expression. Results show that hypothyroidism induces selective oxidative stress in both the hippocampus and amygdala, where the nitrergic system is involved.
研究了甲状腺功能减退对大鼠脑内脂质过氧化（LP）、活性氧（ROS）和一氧化氮合酶（NOS）水平及表达的影响。通过在饮用水中给予甲巯咪唑（60mg/kg/天）诱导甲状腺功能减退。在甲状腺功能减退大鼠的纹状体、运动皮层和小脑中，LP未发生改变，而在甲巯咪唑治疗第三周时，与甲状腺功能正常组相比，甲状腺功能减退大鼠杏仁核和海马中的LP及ROS增加。关于NOS的参与情况，仅海马组成型NOS活性增加，同时nNOS表达增强。结果表明，甲状腺功能减退在海马和杏仁核中诱导了选择性氧化应激，其中氮能系统参与其中。
