Onyeyili P A, Anika S M
Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Maiduguri, Nigeria.
Br Vet J. 1991 Mar-Apr;147(2):155-62. doi: 10.1016/0007-1935(91)90106-W.
The tissue distribution and residue profile of diminazene aceturate was investigated in healthy dogs and in dogs infected with Trypanosoma congolense and Trypanosoma brucei brucei. The drug was administered at 3.5 mg/kg i.m. and tissue samples were taken post mortem from the animals at 48, 72, 120, 168 and 240 h after injection. The drug was distributed to various organs and tissues of the body with the highest concentrations occurring in liver and kidney. Higher drug levels were obtained in the tissues of healthy dogs compared with trypanosome infected animals except in the brain. The levels of residues in the healthy animals were significantly different (P less than 0.05) from those of the infected dogs. The drug residues were still detectable in the tissues of the animals 10 days after drug administration.
对健康犬以及感染刚果锥虫和布氏布氏锥虫的犬进行了乙酰氨基阿苯达唑的组织分布和残留情况研究。药物以3.5毫克/千克的剂量肌肉注射给药，在注射后48、72、120、168和240小时对动物进行剖检并采集组织样本。药物分布于身体的各个器官和组织，肝脏和肾脏中的浓度最高。与感染锥虫的动物相比，健康犬组织中的药物水平更高，但大脑除外。健康动物体内的残留水平与感染犬的残留水平存在显著差异（P小于0.05）。给药10天后，动物组织中仍可检测到药物残留。
