Sharkey J, McBean D E, Kelly P A
Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Scotland, U.K.
Brain Res. 1991 May 10;548(1-2):310-4. doi: 10.1016/0006-8993(91)91138-q.
Local cerebral blood flow and glucose utilisation were measured in both saline (n = 10) and cocaine (10 mg/kg; n = 10) treated rats using [14C]iodoantipyrine and [14C]2-deoxyglucose quantitative autoradiography respectively. In control animals, the ratio of flow to metabolism was 1.40 (r = 0.92) for the 40 brain regions examined. Cocaine treatment altered neither the correlation (r = 0.83) nor the ratio (1.49). Thus, the fundamental relationship between CBF and metabolism remains intact following acute cocaine exposure.
