Lam Yuen Chi, Kum Wan Fung, Durairajan Siva Sundara Kumar, Lu Jia Hong, Man Sui Cheung, Xu Min, Zhang Xiao Fei, Huang Xian Zhang, Li Min
School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong.
J Altern Complement Med. 2008 Jul;14(6):663-71. doi: 10.1089/acm.2007.0011.
To assess the efficacy and safety of acupuncture therapy (monotherapy or adjuvant therapy), compared with placebo, conventional interventions, or no treatment in treating patients with idiopathic Parkinson's disease (IPD).
International electronic database: (1) The Cochrane Controlled Trials Register, (2) Academic Search Premier, (3) ACP Medicine, Alternative Medicine, (4) CINAHL, (5) EBM Reviews, (6) EMBASE, (7) MEDLINE, (8) OLD MEDLINE, (9) ProQuest Medical Library. Chinese electronic databases searched included: (1) VIP, (2) CJN, (3) CBM disk, (4) China Medical Academic Conference. Hand searching was conducted on all appropriate journals. Reference lists of relevant trials and reviews were also searched to identify additional studies.
All randomized controlled trials (RCTs) of any duration comparing monotherapy and adjuvant acupuncture therapy with placebo or no intervention were included.
Data were abstracted independently by Y. C. Lam and S. C. Man onto standardized forms, and disagreements were resolved by discussion.
Ten (10) trials were included, each using a different set of acupoints and manipulation of needles. None of them reported the concealment of allocation. Only two mentioned the number of dropouts. Two (2) used a nonblind method while others did not mention their blinding methods. Nine (9) studies claimed a statistically significant positive effect from acupuncture as compared with their control; only one indicated that there were no statistically significant differences for all variables measured. Only 2 studies described details about adverse events.
There is evidence indicating the potential effectiveness of acupuncture for treating IPD. The results were limited by the methodological flaws, unknowns in concealment of allocation, number of dropouts, and blinding methods in the studies. Large, well-designed, placebo-controlled RCTs with rigorous methods of randomization and adequately concealed allocation, as well as intention-to-treat data analysis are needed.
评估针刺疗法（单一疗法或辅助疗法）相较于安慰剂、传统干预措施或不进行治疗，在治疗特发性帕金森病（IPD）患者时的疗效和安全性。
国际电子数据库：（1）考科蓝对照试验注册库，（2）学术搜索大全，（3）《ACP医学》《替代医学》，（4）护理学与健康领域数据库，（5）循证医学评价，（6）荷兰医学文摘数据库，（7）医学索引数据库，（8）旧医学索引数据库，（9）ProQuest医学图书馆。检索的中文电子数据库包括：（1）维普资讯，（2）中国期刊全文数据库，（3）中国生物医学文献数据库光盘版，（4）中国医学学术会议论文数据库。对所有合适的期刊进行手工检索。还检索了相关试验和综述的参考文献列表以识别其他研究。
纳入所有比较单一疗法和辅助针刺疗法与安慰剂或无干预措施的任何时长的随机对照试验（RCT）。
Y.C. Lam和S.C. Man将数据独立提取到标准化表格中，分歧通过讨论解决。
纳入了10项试验，每项试验使用不同的穴位组和针刺操作方法。没有一项试验报告分配方案的隐藏情况。只有两项试验提到了失访人数。两项试验采用了非盲法，其他试验未提及他们的盲法。9项研究称针刺与对照组相比有统计学显著的积极效果；只有一项研究表明所有测量变量均无统计学显著差异。只有2项研究描述了不良事件的细节。
有证据表明针刺治疗IPD有潜在疗效。研究结果受到方法学缺陷、分配方案隐藏情况不明、失访人数以及盲法等因素的限制。需要开展大型、设计良好、采用安慰剂对照的RCT，采用严格的随机化方法和充分隐藏的分配方案，以及意向性分析。
