Lenas Petros, Moreno Angel, Ikonomou Laertis, Mayer Joerg, Honda Hiroyuki, Novellino Antonio, Pizarro Camilo, Nicodemou-Lena Eleni, Rodergas Silvia, Pintor Jesus
Department of Biochemistry and Molecular Biology IV, Veterinary Faculty, Complutense University of Madrid, Madrid, Spain.
Artif Organs. 2008 Sep;32(9):742-7. doi: 10.1111/j.1525-1594.2008.00599.x. Epub 2008 Jul 30.
Although tissue engineering uses powerful biological tools, it still has a weak conceptual foundation, which is restricted at the cell level. The design criteria at the cell level are not directly related with the tissue functions, and consequently, such functions cannot be implemented in bioartificial tissues with the currently used methods. On the contrary, the field of artificial organs focuses on the function of the artificial organs that are treated in the design as integral entities, instead of the optimization of the artificial organ components. The field of artificial organs has already developed and tested methodologies that are based on system concepts and mathematical-computational methods that connect the component properties with the desired global organ function. Such methodologies are needed in tissue engineering for the design of bioartificial tissues with tissue functions. Under the framework of biomedical engineering, artificial organs and tissue engineering do not present competitive approaches, but are rather complementary and should therefore design a common future for the benefit of patients.
尽管组织工程学使用了强大的生物学工具，但其概念基础仍然薄弱，在细胞层面受到限制。细胞层面的设计标准与组织功能没有直接关联，因此，目前使用的方法无法在生物人工组织中实现这些功能。相反，人工器官领域关注的是作为整体实体进行设计的人工器官的功能，而不是人工器官组件的优化。人工器官领域已经开发并测试了基于系统概念以及将组件特性与所需的整体器官功能相联系的数学计算方法的方法。组织工程学在设计具有组织功能的生物人工组织时需要这样的方法。在生物医学工程的框架下，人工器官和组织工程并非相互竞争的方法，而是互补的，因此应该为了患者的利益设计一个共同的未来。
