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研究项目:查尔斯顿生物工程肾脏项目。

Research project: Charleston Bioengineered Kidney Project.

作者信息

Mironov Vladimir, Drake Christopher, Wen Xuejun

机构信息

Bioprinting Research Center, Medical University of South Carolina, Charleston, SC, USA.

出版信息

Biotechnol J. 2006 Sep;1(9):903-5. doi: 10.1002/biot.200690107.

Abstract

The goal of Charleston Bioengineered Kidney Project is to engineer a functional living human kidney suitable for surgical implantation using principles of directed tissue self-assembly and tissue fusion. This is a multidisciplinary project which incorporates multiple innovative bioengineering technologies and expertise from a broad spectrum of disciplines. The conceptual framework, engineering principles, design, potential cell source as well as the first preliminary data demonstrating the feasibility of the proposed Charleston Bioengineered Kidney Project are outlined. The potential challenges are described. Finally, the experts' opinion about the proposed project is also presented.

摘要

查尔斯顿生物工程肾脏项目的目标是运用定向组织自组装和组织融合原理,构建一个适合手术植入的功能性活体人类肾脏。这是一个多学科项目,融合了多种创新生物工程技术以及来自广泛学科领域的专业知识。文中概述了该项目的概念框架、工程原理、设计、潜在细胞来源,以及展示所提议的查尔斯顿生物工程肾脏项目可行性的首批初步数据。描述了潜在挑战。最后,还呈现了专家对该提议项目的意见。

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