Rogozin Igor B, Makarova Kira S, Pavlov Youri I, Koonin Eugene V
National Center for Biotechnology Information NLM, National Institutes of Health, Bethesda, MD, 20894, USA.
Biol Direct. 2008 Aug 6;3:32. doi: 10.1186/1745-6150-3-32.
A widespread and highly conserved family of apparently inactivated derivatives of archaeal B-family DNA polymerases is described. Phylogenetic analysis shows that the inactivated forms comprise a distinct clade among archaeal B-family polymerases and that, within this clade, Euryarchaea and Crenarchaea are clearly separated from each other and from a small group of bacterial homologs. These findings are compatible with an ancient duplication of the DNA polymerase gene followed by inactivation and parallel loss in some of the lineages although contribution of horizontal gene transfer cannot be ruled out. The inactivated derivative of the archaeal DNA polymerase could form a complex with the active paralog and play a structural role in DNA replication.
本文描述了一个广泛存在且高度保守的古菌B族DNA聚合酶明显失活的衍生物家族。系统发育分析表明，失活形式在古菌B族聚合酶中构成一个独特的进化枝，并且在这个进化枝内，广古菌和泉古菌彼此以及与一小群细菌同源物明显分离。这些发现与DNA聚合酶基因的古老复制随后在一些谱系中失活和平行丢失的情况相符，尽管不能排除水平基因转移的作用。古菌DNA聚合酶的失活衍生物可能与活性旁系同源物形成复合物，并在DNA复制中发挥结构作用。
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