DNA复制：一个复杂的过程。
DNA replication: a complex matter.
作者信息
Frouin Isabelle, Montecucco Alessandra, Spadari Silvio, Maga Giovanni
机构信息
Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, via Abbiategrasso 207, I-27100 Pavia, Italy.
出版信息
EMBO Rep. 2003 Jul;4(7):666-70. doi: 10.1038/sj.embor.embor886.
Abstract
In eukaryotic cells, the essential function of DNA replication is carried out by a network of enzymes and proteins, which work together to rapidly and accurately duplicate the genetic information of the cell. Many of the components of this DNA replication apparatus associate with other cellular factors as components of multiprotein complexes, which act cooperatively in networks to regulate cell cycle progression and checkpoint control, but are distinct from the pre-replication complexes that associate with the origins and regulate their firing. In this review, we summarize current knowledge about the composition and dynamics of these large multiprotein complexes in mammalian cells and their relationships to the replication factories.
摘要
在真核细胞中，DNA复制的基本功能由一个酶和蛋白质网络来执行，这些酶和蛋白质共同作用，快速而准确地复制细胞的遗传信息。这个DNA复制装置的许多组件作为多蛋白复合物的组成部分与其他细胞因子相关联，这些多蛋白复合物在网络中协同作用以调节细胞周期进程和检查点控制，但不同于与复制起点相关联并调节其激活的前复制复合物。在这篇综述中，我们总结了目前关于这些大型多蛋白复合物在哺乳动物细胞中的组成和动态变化及其与复制工厂关系的知识。
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