Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-gu, Seoul 135-710, Republic of Korea.
Eur J Radiol. 2009 Oct;72(1):154-9. doi: 10.1016/j.ejrad.2008.06.025. Epub 2008 Aug 5.
To compare the in vivo gastric injury observed during radiofrequency (RF) ablation of the liver abutting the stomach before and after the intragastric administration of chilled saline.
Twenty RF ablation zones were created in the livers of 10 pigs with a 1-cm-exposed active tip of an internally cooled electrode under ultrasound guidance for 10 min. Ten RF ablation zones were created before (non-saline group) and after (saline group) the intragastric administration of approximately 1000 mL of chilled saline, and 20 RF ablation zones were made in the posterior part of the left lobe abutting the stomach. The frequency and severity of the thermal injury observed in the stomach of the two groups were compared histologically.
All the resected gastric specimens showed thermal injuries of varying degrees of severity. The largest diameter of the gastric injury was significantly smaller in the saline group (mean 1.5 cm; range 1.3-1.8 cm) than in the non-saline group (mean 2.1cm; range 1.8-2.4 cm) (p=0.000). The saline group showed significantly less thermal injury to the muscular layer of the gastric wall by the histopathology (p=0.033).
The intragastric administration of chilled saline might be a useful technique for reducing the severity of gastric injury during RF ablation of the liver abutting the stomach.
比较射频（RF）消融治疗紧邻胃的肝脏时，胃内给予冷盐水前后观察到的体内胃损伤。
在超声引导下，将内部冷却电极的 1 厘米暴露的活动尖端用于 10 分钟，在 10 头猪的肝脏中创建 20 个 RF 消融区。在胃内给予约 1000 毫升冷盐水之前（非盐水组）和之后（盐水组）创建 10 个 RF 消融区，并在胃相邻的左叶后部分别创建 20 个 RF 消融区。比较两组胃中观察到的热损伤的频率和严重程度。
所有切除的胃标本均显示出不同程度的热损伤。盐水组（平均 1.5 厘米；范围 1.3-1.8 厘米）的胃损伤最大直径明显小于非盐水组（平均 2.1 厘米；范围 1.8-2.4 厘米）（p=0.000）。盐水组胃壁肌层的热损伤明显较轻（p=0.033）。
胃内给予冷盐水可能是减少紧邻胃的肝脏 RF 消融时胃损伤严重程度的有用技术。
