Atasayar S, Gürer-Orhan H, Orhan H, Gürel B, Girgin G, Ozgüneş H
Department of Toxicology, Hacettepe University, Sihhiye, Ankara, Turkey.
Exp Toxicol Pathol. 2009 Jan;61(1):23-32. doi: 10.1016/j.etp.2008.04.016. Epub 2008 Aug 5.
In this study, the antioxidant effect of aminoguanidine on nephrotoxicity of a single dose of cisplatin is investigated and compared with the effects of well-known antioxidants vitamin C and E combination. Tubular damage and perivascular inflammation were observed in kidney samples of the cisplatin-administered groups. Aminoguanidine and vitamin C-E combination are found to be capable of preventing these effects of cisplatin. Liver tissues of all groups were intact. Cisplatin-induced oxidative stress was evidenced by significant decrease in glutathione and significant increase in malondialdehyde levels in kidney samples. Antioxidants with cisplatin decreased malondialdehyde levels. Antioxidants with cisplatin prevented the decrease in liver glutathione levels. The nephrotoxicity was confirmed biochemically by significant elevation of serum urea and creatinine levels. Both vitamin C-E combination and aminoguanidine prevented the increase in serum urea levels according to the cisplatin group.
在本研究中，研究了氨基胍对单次剂量顺铂肾毒性的抗氧化作用，并与著名抗氧化剂维生素C和E组合的作用进行了比较。在给予顺铂的组的肾脏样本中观察到肾小管损伤和血管周围炎症。发现氨基胍和维生素C-E组合能够预防顺铂的这些作用。所有组的肝组织均完整。顺铂诱导的氧化应激通过肾脏样本中谷胱甘肽的显著降低和丙二醛水平的显著升高得到证实。与顺铂联用的抗氧化剂降低了丙二醛水平。与顺铂联用的抗氧化剂阻止了肝脏谷胱甘肽水平的降低。通过血清尿素和肌酐水平的显著升高，生化证实了肾毒性。根据顺铂组，维生素C-E组合和氨基胍均阻止了血清尿素水平的升高。
