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2
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Nat Rev Microbiol. 2007 Nov;5(11):873-82. doi: 10.1038/nrmicro1748.
3
Genes at human chromosome 5q31.1 regulate delayed-type hypersensitivity responses associated with Leishmania chagasi infection.人类染色体5q31.1上的基因调控与恰加斯利什曼原虫感染相关的迟发型超敏反应。
Genes Immun. 2007 Oct;8(7):539-51. doi: 10.1038/sj.gene.6364422. Epub 2007 Aug 23.
4
Comparative genomics: from genotype to disease phenotype in the leishmaniases.比较基因组学:利什曼病中从基因型到疾病表型的研究
Int J Parasitol. 2007 Sep;37(11):1173-86. doi: 10.1016/j.ijpara.2007.05.015. Epub 2007 Jun 23.
5
Comparative genomic analysis of three Leishmania species that cause diverse human disease.三种引发不同人类疾病的利什曼原虫物种的比较基因组分析。
Nat Genet. 2007 Jul;39(7):839-47. doi: 10.1038/ng2053. Epub 2007 Jun 17.
6
Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major.多功能TH1细胞确定了疫苗介导的针对硕大利什曼原虫的保护作用的一个相关因素。
Nat Med. 2007 Jul;13(7):843-50. doi: 10.1038/nm1592. Epub 2007 Jun 10.
7
Leishmania chagasi: a tetracycline-inducible cell line driven by T7 RNA polymerase.恰加斯利什曼原虫:一种由T7 RNA聚合酶驱动的四环素诱导细胞系。
Exp Parasitol. 2007 Jul;116(3):205-13. doi: 10.1016/j.exppara.2007.01.001. Epub 2007 Jan 19.
8
Drug policy for visceral leishmaniasis: a cost-effectiveness analysis.内脏利什曼病的药物政策:成本效益分析
Trop Med Int Health. 2007 Feb;12(2):274-83. doi: 10.1111/j.1365-3156.2006.01782.x.
9
Pathology of post-kala-azar dermal leishmaniasis: a light microscopical, immunohistochemical, and ultrastructural study of skin lesions and draining lymph nodes.黑热病后皮肤利什曼病的病理学:皮肤病变及引流淋巴结的光镜、免疫组织化学和超微结构研究
J Cutan Pathol. 2006 Dec;33(12):778-87. doi: 10.1111/j.1600-0560.2006.00531.x.
10
Surrogate markers of immunity to Leishmania major in leishmanin skin test negative individuals from an endemic area re-visited.对来自流行地区的利什曼原虫皮肤试验阴性个体中针对硕大利什曼原虫免疫的替代标志物进行重新研究。
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利什曼病的后基因组学研究:批判性自我评估

Postgenomic research on leishmaniasis: a critical self-appraisal.

作者信息

Kaye Paul M, Blackwell Jenefer M

机构信息

Center for Immunology and Infection, Hull York Medical School and Department of Biology, University of York, York, YO10 5YW, UK.

出版信息

Trends Parasitol. 2008 Sep;24(9):401-5. doi: 10.1016/j.pt.2008.06.004. Epub 2008 Aug 4.

DOI:10.1016/j.pt.2008.06.004
PMID:18684668
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2817896/
Abstract

Scientific conferences, a major feature of academic life, rarely provide the opportunity for self-appraisal of a research field. During a 2007 meeting on leishmaniasis research in the postgenomic era, approximately 60 researchers participated in group discussions that aimed to provide a critical self-appraisal of the state of the field and to highlight major roadblocks that are likely to prevent the translation of new research into tools for leishmaniasis control. These discussions demonstrated a surprising concordance of views and highlighted several crucial areas for future development.

摘要

科学会议是学术生活的一个主要特征,但很少提供对一个研究领域进行自我评估的机会。在2007年召开的关于后基因组时代利什曼病研究的会议上,约60名研究人员参与了小组讨论,旨在对该领域的现状进行批判性自我评估,并突出可能阻碍将新研究转化为利什曼病控制工具的主要障碍。这些讨论显示出了令人惊讶的观点一致性,并突出了未来发展的几个关键领域。