Antoine-Moussiaux Nicolas, Magez Stefan, Desmecht Daniel
Department of Animal Pathology, Veterinary College, University of Liege, 20 Boulevard de Colonster, B43, 4000 Liege, Belgium.
Trends Parasitol. 2008 Sep;24(9):411-8. doi: 10.1016/j.pt.2008.05.010. Epub 2008 Aug 4.
African trypanosomiasis is the collective name for a wide variety of trypanosome infections that affect humans and livestock. In recent years, experimental mice infection models have provided new insights into both human and animal trypanosomiasis. Mouse models seem to be a valuable and versatile tool in trypanosomiasis-associated pathology and immunology research and highlight the variety shown by African trypanosomiases. Indeed, inbred mouse strains have enabled the study of genetic determinants of susceptibility and of the roles of anti-parasite antibodies, inflammatory mediators and anti-inflammatory mediators for each trypanosome species. Remarkable advances relating to the encephalitic stage of sleeping sickness have also been achieved thanks to murine models. The different contributions of murine models to the African trypanosomiases knowledge are presented here. Future search directions are finally proposed, with respect to mouse model opportunities and limitations.
非洲锥虫病是多种影响人类和牲畜的锥虫感染的统称。近年来，实验性小鼠感染模型为人类和动物锥虫病提供了新的见解。小鼠模型似乎是锥虫病相关病理学和免疫学研究中一种有价值且通用的工具，并凸显了非洲锥虫病的多样性。事实上，近交系小鼠品系有助于研究易感性的遗传决定因素以及每种锥虫物种的抗寄生虫抗体、炎症介质和抗炎介质的作用。借助小鼠模型，昏睡病脑炎阶段也取得了显著进展。本文介绍了小鼠模型对非洲锥虫病知识的不同贡献。最后，针对小鼠模型的机遇和局限性提出了未来的研究方向。
