Reichenberg Y, Pomeranz A, Schurr D, Levy E, Stankiewicz H, Elath U, Rosenmann E, Drukker A
Division of Pediatric Nephrology, Shaare Zedek Medical Center, Jerusalem, Israel.
Child Nephrol Urol. 1991;11(1):1-5.
Rats made uremic by 2-stage 5/6 nephrectomy and sham-operated control animals were fed either a normal laboratory chow, a high-sucrose (60%) or a high-fat (10% cholesterol; 20% olive oil) diet, all containing 21% protein and identical amounts of electrolytes, vitamins and trace elements. Serum creatinine levels remained unchanged in the control animals but rose in the 5/6 nephrectomised uremic animals by a factor of 2.7 from a mean of 0.44 +/- 0.05 mg/dl to 1.20 +/- 0.11 mg/dl at 8 weeks, without differences between the dietary groups. During 8 weeks of dietary regimen the high-sucrose and high-fat diets induced significant hypertriglyceridemia, generally similar in control and uremic rats. The uremic animals on a high-sucrose and high-fat diet had the most pronounced rise in serum triglycerides, 331.5 +/- 89.0 and 298.0 +/- 45.0 mg/dl, respectively (control: 159.9 +/- 14.0 mg/dl). After 4 and 8 weeks, only the animals on the high-fat diet had significant hypercholesterolemia, most pronounced in the uremic animals (356 +/- 56.3 mg/dl; control: 71.6 +/- 12.9 mg/dl). The animals in the latter group also had significant proteinuria and renal histologic abnormalities consisting of xanthoma-like glomerular lesions, infiltrates and fibrosis not seen in the other groups of animals. These data indicate that dietary-induced hyperlipidemia of short duration causes or aggravates renal damage in the rat with mild-moderate uremia, induced by ablation.
通过两阶段5/6肾切除术制成尿毒症的大鼠和假手术对照动物分别喂食正常实验室饲料、高糖（60%）或高脂肪（10%胆固醇；20%橄榄油）饮食，所有饮食均含21%蛋白质以及等量的电解质、维生素和微量元素。对照动物的血清肌酐水平保持不变，但5/6肾切除的尿毒症动物血清肌酐水平在8周时从平均0.44±0.05mg/dl升至1.20±0.11mg/dl，升高了2.7倍，各饮食组之间无差异。在8周的饮食方案期间，高糖和高脂肪饮食均引起显著的高甘油三酯血症，在对照大鼠和尿毒症大鼠中总体相似。高糖和高脂肪饮食的尿毒症动物血清甘油三酯升高最为明显，分别为331.5±89.0和298.0±45.0mg/dl（对照：159.9±14.0mg/dl）。4周和8周后，只有高脂肪饮食的动物出现显著的高胆固醇血症，在尿毒症动物中最为明显（356±56.3mg/dl；对照：71.6±12.9mg/dl）。后一组动物还出现显著蛋白尿和肾脏组织学异常，包括其他组动物未见的类黄色瘤样肾小球病变、浸润和纤维化。这些数据表明，短期饮食诱导的高脂血症会导致或加重由切除引起的轻中度尿毒症大鼠的肾损伤。
