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亚洲人群中的社会经济地位与微量白蛋白尿

Socioeconomic status and microalbuminuria in an Asian population.

作者信息

Sabanayagam Charumathi, Shankar Anoop, Saw Seang Mei, Lim Su Chi, Tai E Shyong, Wong Tien Yin

机构信息

Department of Community, Yong Loo Lin School of Medicine, National University of Singapore.

出版信息

Nephrol Dial Transplant. 2009 Jan;24(1):123-9. doi: 10.1093/ndt/gfn447. Epub 2008 Aug 6.

Abstract

BACKGROUND

In studies from developed Western countries, lower socioeconomic status (SES) has been reported to be associated with kidney diseases. However, this hypothesis has not been examined in populations from newly industrialized Asian countries. We evaluated the association between SES and micro/macroalbuminuria in a population-based sample in Singapore.

METHODS

We examined 920 participants of Malay ethnicity aged 40-80 years (49.6% female). SES was defined through education, income and housing type of participants. The main outcome of interest was the presence of micro/macroalbuminuria defined as a urinary albumin-to-creatinine ratio (ACR) >or=17 mg/g for men and >or=25 mg/g for women.

RESULTS

Lower categories of SES were associated with micro/macroalbuminuria; compared to the higher categories of SES, the odds ratio (95% confidence interval) of micro/macroalbuminuria was 1.76 (1.23-2.52) for primary/lower education, 1.64 (1.16-2.31) for income <1000 Singapore dollars (SGD)/retired status, 1.44 (1.01-2.06) for small/medium housing type and 2.37 (1.56-3.60) for the coexistence of all three low SES factors (primary/ below education, income <1000 SGD/retired status and small/medium housing type) compared to <or=1 low SES factor. This pattern of association was consistently present in subgroup analyses by gender and age.

CONCLUSIONS

Lower SES is associated with the presence of micro/macroalbuminuria independent of age, gender, smoking, alcohol intake and body mass index among Malay adults in Singapore.

摘要

背景

在西方国家开展的研究中,有报道称社会经济地位(SES)较低与肾脏疾病有关。然而,这一假设尚未在新兴工业化亚洲国家的人群中得到检验。我们在新加坡一个基于人群的样本中评估了SES与微量/大量白蛋白尿之间的关联。

方法

我们研究了920名年龄在40 - 80岁之间的马来族参与者(女性占49.6%)。SES通过参与者的教育程度、收入和住房类型来定义。主要关注的结果是微量/大量白蛋白尿的存在,定义为男性尿白蛋白与肌酐比值(ACR)≥17 mg/g,女性≥25 mg/g。

结果

较低的SES类别与微量/大量白蛋白尿相关;与较高的SES类别相比,小学/低学历者微量/大量白蛋白尿的比值比(95%置信区间)为1.76(1.23 - 2.52),收入<1000新加坡元(SGD)/退休状态者为1.64(1.16 - 2.31),中小住房类型者为1.44(1.01 - 2.06),与≤1个低SES因素相比,所有三个低SES因素(小学/以下学历、收入<1000 SGD/退休状态和中小住房类型)并存时为2.37(1.56 - 3.60)。这种关联模式在按性别和年龄进行的亚组分析中始终存在。

结论

在新加坡的马来成年人中,较低的SES与微量/大量白蛋白尿的存在相关,且独立于年龄、性别、吸烟、饮酒和体重指数。

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