用叔丁基 - P4碱活化有机锌试剂用于无过渡金属催化的SN2'反应。

Activation of organozinc reagents with t-Bu-P4 base for transition metal-free catalytic SN2' reaction.

作者信息

Kobayashi Koji, Ueno Masahiro, Naka Hiroshi, Kondo Yoshinori

机构信息

Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki Aza Aoba 6-3, Aoba-ku, Sendai 980-8578, Japan.

出版信息

Chem Commun (Camb). 2008 Aug 28(32):3780-2. doi: 10.1039/b807169a. Epub 2008 Jun 20.

DOI:10.1039/b807169a

PMID:18685775

Abstract

The t-Bu-P4 base was found to be an excellent catalyst for activating organozinc reagents and was used to promote the S(N)2' reaction of alpha,beta-unsaturated esters bearing a gamma-chloride using various organozinc reagents: these reactions proceeded in high yields with excellent chemo-and regioselectivity.

摘要

发现叔丁基-P4碱是活化有机锌试剂的优良催化剂，并用于促进带有γ-氯的α,β-不饱和酯与各种有机锌试剂的S(N)2'反应：这些反应以高产率进行，具有优异的化学和区域选择性。