Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki-aza Aoba 6-3, Aoba-ku, Sendai 980-8578, Japan.
Chemistry. 2009 Sep 28;15(38):9805-9. doi: 10.1002/chem.200900556.
The tBu-P4 base was found to be an excellent catalyst for the activation of organozinc reagents. The base was used to promote the S(N)2' reaction of alpha,beta-unsaturated esters bearing a gamma-chloride in the reactions with various organozinc reagents in the presence of LiCl. The reactions proceeded in high yield with excellent chemo-and regioselectivity. The role of LiCl appears to be the activation of the gamma-chloride of the alpha,beta-unsaturated esters, which was confirmed by NMR spectroscopic study.
叔丁基膦（tBu-P4）碱被发现是一种极好的有机锌试剂的活化催化剂。该碱被用于在 LiCl 的存在下促进带有γ-氯代物的α，β-不饱和酯与各种有机锌试剂的 S（N）2'反应。这些反应在高收率下具有极好的化学和区域选择性。LiCl 的作用似乎是激活α，β-不饱和酯的γ-氯代物，这一点通过 NMR 光谱研究得到了证实。
