2-杂环有机锌试剂与芳基氯的温和 Negishi 交叉偶联反应。
A mild Negishi cross-coupling of 2-heterocyclic organozinc reagents and aryl chlorides.
机构信息
Department of Process Research, Merck Research Laboratories, P.O. Box 2000 Rahway, New Jersey 07065, USA.
出版信息
J Org Chem. 2010 Dec 3;75(23):8330-2. doi: 10.1021/jo1018798. Epub 2010 Nov 3.
PMID:21047088
Abstract
A mild Negishi cross-coupling of 2-heterocyclic organozinc reagents and aryl chlorides is described. The use of Pd(2)(dba)(3) and X-Phos as a ligand provides high yields for many examples. An efficient method to generate the organozinc reagents at room temperature is also demonstrated.
摘要
一种温和的 Negishi 交叉偶联反应，涉及 2-杂环有机锌试剂和芳基氯。使用 Pd(2)(dba)(3) 和 X-Phos 作为配体，可以为许多例子提供高产率。还展示了一种在室温下生成有机锌试剂的有效方法。
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