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硬膜外腔镜检查术中进行粘连松解和靶向类固醇/局部麻醉药注射可减轻慢性坐骨神经痛患者的疼痛并减少感觉神经功能障碍。

Adhesiolysis and targeted steroid/local anesthetic injection during epiduroscopy alleviates pain and reduces sensory nerve dysfunction in patients with chronic sciatica.

作者信息

Sakai Tetsuya, Aoki Hiroshi, Hojo Minoru, Takada Masafumi, Murata Hiroaki, Sumikawa Koji

机构信息

Department of Anesthesiology, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.

出版信息

J Anesth. 2008;22(3):242-7. doi: 10.1007/s00540-008-0616-4. Epub 2008 Aug 7.

Abstract

PURPOSE

The aim of this study was to evaluate the effect of adhesiolysis followed by the injection of steroid and local anesthetic during epiduroscopy on sensory nerve function, pain, and functional disability in patients with chronic sciatica.

METHODS

Epidural adhesiolysis, using epiduroscopy, followed by the injection of steroid and local anesthetic, was scheduled in 19 patients with chronic sciatica refractory to lumbar epidural block. Sensory nerve function in the legs was tested with a series of 2000-Hz (Abeta-fiber), 250-Hz (Adelta-fiber), and 5-Hz (C-fiber) stimuli, using the current perception threshold (CPT), and CPT values and intensity of pain and Roland Morris Disability Questionnaire (RMDQ) scores were assessed before and 1 and 3 months after the epiduroscopy.

RESULTS

At all frequencies, the CPT values in the affected legs of patients before the epiduroscopy were significantly higher than those in the unaffected legs. Epidural adhesiolysis was successfully performed in 16 of the 19 patients. In these patients, the CPT values at 2000 and 250 Hz, and the pain and RMDQ scores 1 and 3 months after the epiduroscopy were significantly lower than those before the epiduroscopy, while the CPT value at 5 Hz did change.

CONCLUSION

Epidural adhesiolysis followed by the injection of steroid and local anesthetic during epiduroscopy alleviated pain, and functional disability, and reduced dysfunction of Abeta and Adelta fibers in patients with chronic sciatica.

摘要

目的

本研究旨在评估在硬膜外腔镜检查期间进行粘连松解术并注射类固醇和局部麻醉剂对慢性坐骨神经痛患者感觉神经功能、疼痛及功能障碍的影响。

方法

计划对19例经腰椎硬膜外阻滞治疗无效的慢性坐骨神经痛患者进行硬膜外腔镜下粘连松解术,随后注射类固醇和局部麻醉剂。使用电流感觉阈值(CPT),通过一系列2000赫兹(Aβ纤维)、250赫兹(Aδ纤维)和5赫兹(C纤维)刺激测试腿部的感觉神经功能,并在硬膜外腔镜检查前、检查后1个月和3个月评估CPT值、疼痛强度及罗兰·莫里斯功能障碍问卷(RMDQ)评分。

结果

在所有频率下,硬膜外腔镜检查前患者患侧腿部的CPT值均显著高于未患侧腿部。19例患者中有16例成功进行了硬膜外粘连松解术。在这些患者中,硬膜外腔镜检查后1个月和3个月时,2000赫兹和250赫兹的CPT值、疼痛及RMDQ评分均显著低于检查前,而5赫兹的CPT值未发生变化。

结论

在硬膜外腔镜检查期间进行粘连松解术并注射类固醇和局部麻醉剂可缓解慢性坐骨神经痛患者的疼痛和功能障碍,并减少Aβ和Aδ纤维功能障碍。

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