Successful transition to buprenorphine in a patient with methadone-induced torsades de pointes.

作者信息

Esses Jason Levi, Rosman Jonathan, Do Lien Thanh, Schweitzer Paul, Hanon Sam

机构信息

Department of Cardiology, Beth Israel Medical Center, 1st Ave. at 16th Street, Baird Hall, 5th Floor, New York, NY, 10003, USA.

出版信息

J Interv Card Electrophysiol. 2008 Nov;23(2):117-9. doi: 10.1007/s10840-008-9280-8. Epub 2008 Aug 7.

DOI:10.1007/s10840-008-9280-8

PMID:18686025

Abstract

A 56-year-old-man presented with syncope and torsades de pointes secondary to methadone-induced QT prolongation. After transition from methadone to buprenorphine, a partial mu-opiate-receptor agonist and a kappa-opiate-receptor antagonist, the QT normalized and ventricular arrhythmias resolved. Buprenorphine should be used for opiate dependence and chronic pain in patients with methadone-induced QT prolongation and as first line therapy in patients with risk factors for torsades de pointes.

摘要