Azin Hossein, Ashjazadeh Nahid
Department of Neurology, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Acta Neurol Taiwan. 2008 Jun;17(2):82-7.
Cerebral venous sinus thrombosis (CVST) is a disease with potentially serious consequences and usually affecting young to middle aged people. This study was designed to investigate the clinical features, and predisposing and prognostic factors of CVST in a prospective series of 61 patients.
This prospective study comprised 61 consecutive patients with confirmed diagnosis of CVST who were hospitalized in Namazi Hospital in Shiraz, south of Iran, between January 2000 and August 2003. The diagnosis was confirmed using conventional MRI or cerebral angiography.
The male to female ratio was 1/3.1. The mean age of patients was 35.6 +/- 12.1 years. Headache was seen in 91.8% of the patients. The most frequent risk factor was oral contraceptive consumption (62.2%). Elevation of ESR and CRP titer were seen in 37.7%, and 36.1% of patients, respectively. Involvement of superior sagittal sinus and lateral sinus was 80.3% and 41%, respectively. The final diagnosis was neurobechet in 5 ppatients (8.2%). The fatality rate was 14.7% and an altered consciousness was associated with poor prognosis.
CVST presents with a wide spectrum of symptoms and signs. Headache was the most frequent symptom. Women who used OCP were especially at risk. Because of moderate to high mortality rate, patients at increased risk of death, specially comatose patients, should be closely monitored.
脑静脉窦血栓形成（CVST）是一种可能产生严重后果的疾病，通常影响中青年人群。本研究旨在调查61例CVST患者的前瞻性系列研究中的临床特征、诱发因素和预后因素。
这项前瞻性研究纳入了2000年1月至2003年8月期间在伊朗南部设拉子的纳马齐医院住院的61例确诊为CVST的连续患者。诊断通过传统MRI或脑血管造影得以证实。
男女比例为1/3.1。患者的平均年龄为35.6±12.1岁。91.8%的患者出现头痛。最常见的危险因素是口服避孕药的使用（62.2%）。分别有37.7%和36.1%的患者出现血沉（ESR）升高和C反应蛋白（CRP）滴度升高。上矢状窦和外侧窦受累分别为80.3%和41%。最终诊断为神经白塞病的患者有5例（8.2%）。死亡率为14.7%，意识改变与预后不良相关。
CVST表现出广泛的症状和体征。头痛是最常见的症状。使用口服避孕药的女性尤其危险。由于死亡率处于中高水平，死亡风险增加的患者，特别是昏迷患者，应密切监测。
