波兰人群中1型、2型和3型辅助性T细胞通路中的基因变异与胃癌风险
Genetic variants in T helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish population.
作者信息
Mahajan Rajeev, El-Omar Emad M, Lissowska Jolanta, Grillo Paolo, Rabkin Charles S, Baccarelli Andrea, Yeager Meredith, Sobin Leslie H, Zatonski Witold, Channock Stephen J, Chow Wong-Ho, Hou Lifang
机构信息
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
出版信息
Jpn J Clin Oncol. 2008 Sep;38(9):626-33. doi: 10.1093/jjco/hyn075. Epub 2008 Aug 7.
Host immune responses are known determinants of gastric cancer susceptibility. We previously reported an increased gastric cancer risk associated with common variants of several T helper type 1 (Th1) cytokine genes in a population-based case-control study in Warsaw, Poland. In the present study, we augmented our investigation to include additional Th1 genes as well as key genes in the Th2 and Th3 pathways. Analysis of 378 cases and 435 age- and sex-matched controls revealed associations for polymorphisms in the Th1 IL7R gene and one polymorphism in the Th2 IL5 gene. The odd ratios (ORs) for IL7R rs1494555 were 1.4 [95% confidence interval (CI), 1.0-1.9] for A/G and 1.5 (95% CI, 1.0-2.4) for G/G carriers relative to A/A carriers (P = 0.04). The ORs for IL5 rs2069812 were 0.9 (95% CI, 0.7-1.3) for C/T and 0.6 (95% CI, 0.3-1.0) T/T carriers compared with C/C carriers (P = 0.03). These results suggest that IL5 rs2069812 and IL7R rs1389832, rs1494556 and rs1494555 polymorphisms may contribute to gastric cancer etiology.
宿主免疫反应是已知的胃癌易感性决定因素。我们之前在波兰华沙开展的一项基于人群的病例对照研究中报告称，几种1型辅助性T细胞（Th1）细胞因子基因的常见变异与胃癌风险增加有关。在本研究中，我们扩大了调查范围，纳入了更多的Th1基因以及Th2和Th3途径中的关键基因。对378例病例和435例年龄及性别匹配的对照进行分析后发现，Th1的IL7R基因多态性和Th2的IL5基因中的一个多态性存在关联。相对于A/A携带者，IL7R rs1494555的A/G携带者的优势比（OR）为1.4 [95%置信区间（CI），1.0 - 1.9]，G/G携带者的OR为1.5（95% CI，1.0 - 2.4）（P = 0.04）。与C/C携带者相比，IL5 rs2069812的C/T携带者的OR为0.9（95% CI，0.7 - 1.3），T/T携带者的OR为0.6（95% CI，0.3 - 1.0）（P = 0.03）。这些结果表明，IL5 rs2069812以及IL7R rs1389832、rs1494556和rs1494555多态性可能与胃癌病因有关。
Zotero 插件