The Second Hospital of Lanzhou University, Lanzhou, China.
Blood. 2011 Jan 13;117(2):585-90. doi: 10.1182/blood-2010-07-295097. Epub 2010 Oct 15.
We conducted a population-based, case-control study in Connecticut women to test the hypothesis that genetic variations in Th1 and Th2 cytokine genes modify the relationship between body mass index (BMI) and risk of non-Hodgkin lymphoma (NHL). Compared with those with BMI less than 25 kg/m(2), women with BMI more than or equal to 25 kg/m(2) had 50% to 90% increased risk of NHL among women who carried IFNGR2 (rs9808753) AA, IL5 (rs2069812) CT/TT, IL7R (rs1494555) AA, and TNF (rs1799724) CC genotypes, but no increased risk among women with IFNGR2 AG/GG, IL5 CC, IL7R AG/GG, and TNF CT/TT genotypes. A significant interaction with BMI was only observed for IFNGR2 (rs9808753 P(forinteraction) = .034) and IL7R (rs1494555 P(forinteraction) = .016) for NHL overall; IL7R (rs1494555 P(forinteraction) = .016) and TNF (1799724 P(forinteraction) = .031) for B-cell lymphoma; and IL5 (rs2069812 P(forinteraction) = .034) for T-cell lymphoma. After stratification by common B-cell lymphoma subtypes, a significant interaction was observed for IFNGR2 (rs9808753 P(forinteraction) = .006), IL13 (rs20541 P(forinteraction) = .019), and IL7R (rs1494555 P(forinteraction) = .012) for marginal zone B-cell lymphoma; IL7R (rs1494555 P(forinteraction) = .017) for small lymphocytic lymphoma/chronic lymphocytic leukemia; and IL12A (rs568408 P(forinteraction) = .013) and TNF (1799724 P(forinteraction) = .04) for follicular lymphoma. The results suggest that common genetic variation in Th1/Th2 pathway genes may modify the association between BMI and NHL risk.
我们在康涅狄格州女性中进行了一项基于人群的病例对照研究，以检验以下假设：Th1 和 Th2 细胞因子基因的遗传变异会改变体重指数（BMI）与非霍奇金淋巴瘤（NHL）风险之间的关系。与 BMI<25kg/m2 的女性相比，BMI≥25kg/m2 的女性携带 IFNGR2（rs9808753）AA、IL5（rs2069812）CT/TT、IL7R（rs1494555）AA 和 TNF（rs1799724）CC 基因型时，NHL 的风险增加 50%至 90%，而携带 IFNGR2 AG/GG、IL5 CC、IL7R AG/GG 和 TNF CT/TT 基因型的女性中 NHL 风险则无增加。仅在 IFNGR2（rs9808753，P（交互作用）=0.034）和 IL7R（rs1494555，P（交互作用）=0.016）基因上观察到与 BMI 的显著交互作用，用于 NHL 整体；IL7R（rs1494555，P（交互作用）=0.016）和 TNF（rs1799724，P（交互作用）=0.031）用于 B 细胞淋巴瘤；以及 IL5（rs2069812，P（交互作用）=0.034）用于 T 细胞淋巴瘤。在常见 B 细胞淋巴瘤亚型分层后，IFNGR2（rs9808753，P（交互作用）=0.006）、IL13（rs20541，P（交互作用）=0.019）和 IL7R（rs1494555，P（交互作用）=0.012）基因上的交互作用对于边缘区 B 细胞淋巴瘤具有统计学意义；IL7R（rs1494555，P（交互作用）=0.017）对于小淋巴细胞性淋巴瘤/慢性淋巴细胞白血病；以及 IL12A（rs568408，P（交互作用）=0.013）和 TNF（rs1799724，P（交互作用）=0.04）基因对于滤泡性淋巴瘤具有统计学意义。这些结果表明，Th1/Th2 途径基因的常见遗传变异可能会改变 BMI 与 NHL 风险之间的关联。
