Gupta Anurag, Raja A, Mahadevan A, Shankar S K
Department of Neurosurgery, KMC, Manipal, India.
Neurol India. 2008 Apr-Jun;56(2):189-91.
Toxoplasmosis is a common opportunistic infection in patients with AIDS in whom it frequently presents as intracranial space-occupying lesions. In the immunocompetent patient the most common manifestation is as asymptomatic cervical lymphadenopathy which may be associated with vague systemic manifestations such as fever or myalgia. In very rare cases people with normal immunity may present with meningoencephalitis polymyositis or myocarditis. It is very rare to encounter a brainstem granuloma due to toxoplasma infection in such patients. We report a non-immunocompromised man who presented with multiple cranial nerve palsies due to a brainstem lesion, which turned out to be a toxoplasma granuloma. He recovered completely after a four-week course of Pyrimethamine and Sulphadoxine. An extensive search of the literature failed to reveal any prior reports of a similar nature. This case is being reported because of its rarity and the complete recovery made by the patient.
弓形虫病是艾滋病患者常见的机会性感染,常表现为颅内占位性病变。在免疫功能正常的患者中,最常见的表现是无症状性颈部淋巴结病,可能伴有发热或肌痛等模糊的全身症状。在极少数情况下,免疫功能正常的人可能会出现脑膜脑炎、多发性肌炎或心肌炎。在此类患者中,因弓形虫感染导致脑干肉芽肿极为罕见。我们报告一例非免疫功能低下的男性患者,因脑干病变出现多发性颅神经麻痹,结果发现是弓形虫肉芽肿。经过四周的乙胺嘧啶和磺胺多辛治疗,他完全康复。广泛查阅文献未发现任何类似性质的先前报道。由于该病例罕见且患者完全康复,故予以报道。