Yavuz E, Aydin F, Seyhan A, Topuz S, Karagenc Y, Tuzlali S, Ilhan R, Iplikci A
Department of Pathology, Istanbul School of Medicine, Istanbul University, Capa, Topkapi, Istanbul 34390, Turkey.
Placenta. 2006 Jun-Jul;27(6-7):780-2. doi: 10.1016/j.placenta.2005.07.002. Epub 2005 Aug 29.
We present a case of placental toxoplasmosis with granulomatous villitis. The patient was a 26-year-old gravida 1 female with the findings of intrauterine death at 16th week of gestation. The pregnancy was terminated. Pathological examination revealed an autolysed fetus and a placenta with necrotizing granulomas within the villous stroma. Encysted Toxoplasma gondii was rarely observed within the granulomas and serologic examination of the mother confirmed acute toxoplasmosis. A fluorocein in situ hybridization examination, using sex chromosome probes, revealed that the villous granulomas were formed by inflammatory cells, originated from the maternal immune system. In conclusion, T. gondii should be taken into consideration as a rare cause of placental granulomatous inflammation. To the best of our knowledge, this is the first case of granulomatous villitis due to toxoplasmosis, in which formation by maternal inflammatory cells has been demonstrated.
我们报告一例伴有肉芽肿性绒毛炎的胎盘弓形虫病。患者为一名26岁初孕妇，在妊娠第16周时发现宫内死亡。妊娠终止。病理检查显示胎儿自溶，胎盘绒毛间质内有坏死性肉芽肿。在肉芽肿内很少观察到包囊化的弓形虫，母亲的血清学检查证实为急性弓形虫病。使用性染色体探针进行的荧光原位杂交检查显示，绒毛肉芽肿由源自母体免疫系统的炎性细胞形成。总之，弓形虫应被视为胎盘肉芽肿性炎症的罕见病因。据我们所知，这是首例由弓形虫病引起的肉芽肿性绒毛炎，其中已证实由母体炎性细胞形成。
