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患有下腔静脉血栓形成的儿童进行肾移植需要仔细评估和规划。

Renal transplantation in children with thrombosis of the inferior vena cava requires careful assessment and planning.

作者信息

Salvatierra Oscar, Concepcion Waldo, Sarwal Minnie M

出版信息

Pediatr Nephrol. 2008 Dec;23(12):2107-9. doi: 10.1007/s00467-008-0951-6. Epub 2008 Aug 8.

DOI:10.1007/s00467-008-0951-6
PMID:18688652
Abstract

Children with end-stage renal disease and inferior vena cava (IVC) thrombosis are rare, and their condition is complex and high risk for renal transplantation. Detailed imaging studies of the recipient's abdominal vasculature should be carried out prior to transplantation, followed by careful pre-operative joint planning by the pediatric transplant surgeon and nephrologist. Critical decisions need to be made as to whether a deceased child's kidney or an adult-sized kidney is to be used, and if the latter, whether it should be from a deceased or living donor. In addition, the contemplated site of the donor's renal vein anastomosis needs to be determined with a consideration of the possible consequences of the various choices. Sixteen cases of renal transplantation in children with pre-existing IVC thrombosis are reviewed, including the three reported by Shenoy et al. in this journal. With a full understanding of the difficulties noted, renal transplantation in a small child with IVC thrombosis can be successful. However, it requires thorough recipient assessment, coupled with a careful and thoughtful examination of options, to determine the best possible approach to the transplantation.

摘要

患有终末期肾病且伴有下腔静脉(IVC)血栓形成的儿童非常罕见,他们的病情复杂,肾移植风险高。移植前应对受者的腹部血管系统进行详细的影像学检查,随后由小儿移植外科医生和肾病学家进行仔细的术前联合规划。对于是使用已故儿童的肾脏还是成人尺寸的肾脏,以及如果使用后者,是来自已故供体还是活体供体,都需要做出关键决策。此外,在考虑各种选择可能产生的后果的情况下,需要确定供体肾静脉吻合的预期部位。本文回顾了16例患有IVC血栓形成的儿童肾移植病例,包括Shenoy等人在本期刊上报道的3例。在充分了解所指出的困难的情况下,患有IVC血栓形成的幼儿进行肾移植可以成功。然而,这需要对受者进行全面评估,并仔细、深入地考虑各种选择,以确定最佳的移植方法。

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Pediatr Nephrol. 2008 Dec;23(12):2107-9. doi: 10.1007/s00467-008-0951-6. Epub 2008 Aug 8.
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Clin Transplant. 2018 Apr;32(4):e13223. doi: 10.1111/ctr.13223. Epub 2018 Mar 14.
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Successful Kidney Transplantation in Children With a Compromised Inferior Vena Cava.下腔静脉受损儿童的成功肾移植
Transplant Direct. 2016 May 23;2(6):e82. doi: 10.1097/TXD.0000000000000592. eCollection 2016 Jun.

本文引用的文献

1
Successful renal transplantation in children in the presence of thrombosis of the inferior vena cava.在下腔静脉血栓形成的情况下儿童成功进行肾移植。
Pediatr Nephrol. 2008 Dec;23(12):2261-5. doi: 10.1007/s00467-007-0736-3. Epub 2008 Feb 6.
2
Good MRI images: to Gad or not to Gad?优质的磁共振成像(MRI)图像:用钆对比剂还是不用?
Pediatr Nephrol. 2007 Sep;22(9):1239-42. doi: 10.1007/s00467-007-0509-z. Epub 2007 May 22.
3
Renal transplant in children with previous inferior vena cava thrombosis.曾患下腔静脉血栓形成的儿童的肾移植
Pediatr Transplant. 2007 Jun;11(4):419-21. doi: 10.1111/j.1399-3046.2007.00680.x.
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Successful renal transplantation in high-risk small children with a completely thrombosed inferior vena cava.下腔静脉完全血栓形成的高危小儿成功肾移植。
Transplantation. 2006 Nov 15;82(9):1148-52. doi: 10.1097/01.tp.0000236644.76359.47.
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Pediatr Transplant. 2000 Feb;4(1):28-34. doi: 10.1034/j.1399-3046.2000.00078.x.
6
Successful transplantation of adult-sized kidneys into infants requires maintenance of high aortic blood flow.将成人尺寸的肾脏成功移植到婴儿体内需要维持高主动脉血流量。
Transplantation. 1998 Oct 15;66(7):819-23. doi: 10.1097/00007890-199810150-00001.