Cole Gretchen A, Garner Michael M, Carpenter James W, Kuroki Keiichi, Bowlus Rachel A, Latimer Kenneth S
Veterinary Medical Teaching Hospital, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA.
J Avian Med Surg. 2008 Jun;22(2):127-37. doi: 10.1647/2007-042R.1.
A 1.5-year-old male Moluccan cockatoo (Cacatua moluccensis) presented to Kansas State University Veterinary Medical Teaching Hospital with a 4-month history of lethargy and weakness. Hematologic and radiographic diagnostic testing revealed profound leukocytosis and coelomic and pulmonary granulomatous masses of unknown origin. The bird died during laparoscopic evaluation under general anesthesia. Necropsy revealed multiple pulmonary and hepatic soft-tissue nodules and an intracoelomic mass over the left kidney communicating with external subcutaneous masses and a pericloacal mass of similar gross appearance. Histopathologic findings identified a severe, disseminated, inflammatory infiltration of multiple tissues and multiple granulomas containing bizarre multinucleated cells. No causative agent of this granulomatous disease was identified. To our knowledge, this is the first report of systemic atypical granulomatous disease in Moluccan cockatoo. Traditional causes of granulomatous disease include mycotic disease, bacterial (ie, Mycobacterium) disease, and neoplasia. Attempts to identify an causative agent or neoplasia were unsuccessful. A retrospective review of pathology records revealed 2 additional cases with identical pathologic lesions. All 3 cases occurred in young Moluccan cockatoos and are assumed to be a disease of unknown origin that could be unique to this species.
一只1.5岁的雄性摩鹿加凤头鹦鹉（Cacatua moluccensis）被送至堪萨斯州立大学兽医学院教学医院，有4个月的嗜睡和虚弱病史。血液学和放射学诊断检查显示有严重的白细胞增多症以及来源不明的体腔和肺部肉芽肿性肿块。这只鸟在全身麻醉下进行腹腔镜评估时死亡。尸检发现多个肺和肝软组织结节，以及左肾上方的一个体腔内肿块，与外部皮下肿块相通，还有一个外观相似的泄殖腔周围肿块。组织病理学检查结果显示多个组织有严重的、弥漫性的炎症浸润，以及多个含有奇异多核细胞的肉芽肿。未发现这种肉芽肿性疾病的病原体。据我们所知，这是摩鹿加凤头鹦鹉系统性非典型肉芽肿性疾病的首例报告。肉芽肿性疾病的传统病因包括真菌病、细菌性（如分枝杆菌）疾病和肿瘤形成。试图确定病原体或肿瘤均未成功。对病理记录的回顾性研究发现另外2例有相同的病理病变。所有3例均发生在年轻的摩鹿加凤头鹦鹉身上，被认为是一种来源不明的疾病，可能是该物种所特有的。
