Pawsat Grace, Hoggard Nathan, Duvall Abigail, Flatland Bente
Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA,
Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA.
J Avian Med Surg. 2023 Mar;36(4):406-413. doi: 10.1647/22-00006.
A 32-year-old male salmon-crested cockatoo () was diagnosed by cytology with bilateral cubital lymphoma and mycobacteriosis. Polymerase chain reaction assay testing confirmed . This patient was subsequently humanely euthanized. Postmortem histopathology confirmed both diagnoses with findings of multicentric lymphoma, acid-fast bacilli, and severe degenerative changes in all synovial joints examined. Immunohistochemical staining for paired box protein 5 of the cubital mass was positive for a high percentage of B-cell lymphocytes, consistent with B-cell lymphoma. This unusual case of two major diseases presenting concurrently in one patient raises the question of whether the pathogenesis could have an interdependent relationship. Mycobacteriosis, severe degenerative joint changes, or both may have stimulated lymphocytes, eventually leading to lymphoma. Additional screening and monitoring for comorbidities may be advised if 1 of these diseases are diagnosed in companion avian species.
一只32岁的雄性鲑色凤头鹦鹉被细胞学诊断为双侧肘部淋巴瘤和分枝杆菌病。聚合酶链反应检测证实了……该患者随后被实施安乐死。尸检组织病理学通过多中心淋巴瘤、抗酸杆菌以及所有检查的滑膜关节中的严重退行性变的发现证实了这两种诊断。对肘部肿块的配对盒蛋白5进行免疫组织化学染色，结果显示高比例的B细胞淋巴细胞呈阳性，符合B细胞淋巴瘤。这一在同一患者中同时出现两种主要疾病的罕见病例引发了发病机制是否可能存在相互依存关系的问题。分枝杆菌病、严重的退行性关节改变或两者都可能刺激淋巴细胞，最终导致淋巴瘤。如果在伴侣鸟类中诊断出这些疾病中的一种，建议对合并症进行额外的筛查和监测。
