Markina N V, Perepelkina O V, Poletaeva I I
Zh Vyssh Nerv Deiat Im I P Pavlova. 2008 May-Jun;58(3):368-75.
Neonatal DBA/2J, 101/HY and CBA/Lac/Sto mice (2-7-day-old) were subcutaneously injected with caffeine (200 mg/kg), piracetam (50 mg/kg) or distilled water. At the age of 1 month, they were tested for audiogenic seizure susceptibility (SS). The neonatal injections changed SS in 1-month-old mice in a genotype-dependent manner. Distilled water (control of neonatal pain stimulation) slightly reduced the audiogenic fit severity (arbitrary scores) the effect being most distinct in DBA/2J, less strong in 101/HY strain and absent in CBA. Caffeine neonatal injections induced slight changes in DBA/2J, no changes in CBA and increased SS in 101/HY mice. Piracetam reduced fit intensity in DBA/2J mice but increased it in CBA and, especially, in 101/HY strain. Genotype-dependent differences in physiological mechanisms of audiogenic seizures may be responsible for different remote effects of early treatment.
将新生的DBA/2J、101/HY和CBA/Lac/Sto小鼠（2至7日龄）皮下注射咖啡因（200毫克/千克）、吡拉西坦（50毫克/千克）或蒸馏水。在1月龄时，对它们进行听源性癫痫易感性（SS）测试。新生期注射以基因型依赖的方式改变了1月龄小鼠的SS。蒸馏水（新生期疼痛刺激的对照）略微降低了听源性惊厥的严重程度（任意评分），这种效应在DBA/2J小鼠中最为明显，在101/HY品系中较弱，而在CBA小鼠中则不存在。新生期注射咖啡因在DBA/2J小鼠中引起轻微变化，在CBA小鼠中无变化，而在101/HY小鼠中增加了SS。吡拉西坦降低了DBA/2J小鼠的惊厥强度，但在CBA小鼠中尤其是在101/HY品系中增加了惊厥强度。听源性癫痫生理机制的基因型依赖性差异可能是早期治疗产生不同远期效应的原因。
