Sharetskiĭ A N, Surinov B P, Abramova M R, Karpova N A
Radiats Biol Radioecol. 2008 May-Jun;48(3):342-5.
The influence of volatile urine chemosignals of irradiated (4 Gy) mice on the primary humoral immune response to sheep red blood cells in intact recipients was investigated. It was demonstrated that the direction of immunomodulatory effect is dependent upon the time at which the postradiation chemosignals was initially applied. The antibody response to antigen was markedly suppressed in mice that were exposed before antigen injection. When chemosignals applied immediately following inoculation of antigen the antibody response was unaffected. The immune response was increased when chemosignals was loadeded for 1-10 days after immunization. The possible mechanisms of immunomodulation are considered.
研究了受辐照（4 Gy）小鼠的挥发性尿液化学信号对完整受体中针对绵羊红细胞的初次体液免疫反应的影响。结果表明，免疫调节作用的方向取决于辐射后化学信号最初施加的时间。在抗原注射前接触化学信号的小鼠中，对抗原的抗体反应明显受到抑制。当在接种抗原后立即施加化学信号时，抗体反应不受影响。在免疫后1 - 10天加载化学信号时，免疫反应增强。文中还考虑了免疫调节的可能机制。
