Sharetskiĭ A N, Kharlamov V A, Surinov B P
Radiats Biol Radioecol. 2012 May-Jun;52(3):229-33.
The ability of post-radiation (4 Gy) bystander chemosignals (the volatile components of mouse urine) to distantly modulate the humoral immune response to the sheep red blood cells in the spleen and popliteal lymph nodes of intact recipients has been investigated. It was shown that the exposure of animals to chemosignals before antigen injection resulted in the decrease and increase of the immune response in the spleen and lymph nodes, respectively. When animals were exposed to chemosignals after the antigenic stimulus, an increased immune response was observed in both spleen and lymph nodes. The contribution of radiation-induced bystander signaling in the response of socially organized animals to the effect of ionizing irradiation is discussed.
研究了辐射后（4 Gy）旁观者化学信号（小鼠尿液的挥发性成分）对完整受体脾脏和腘淋巴结中针对绵羊红细胞的体液免疫反应进行远距离调节的能力。结果表明，在注射抗原前让动物暴露于化学信号，分别导致脾脏和淋巴结中免疫反应的降低和增加。当动物在抗原刺激后暴露于化学信号时，脾脏和淋巴结中的免疫反应均增强。本文讨论了辐射诱导的旁观者信号在群居动物对电离辐射效应的反应中的作用。
