聚（乙二醇）连接的pH响应网络的动力学
Dynamics of Poly(ethylene glycol)-Tethered, pH Responsive Networks.
作者信息
Brock Thomas J, Tingsanchali Joseph H, Rosales Adrianne M, Creecy Courtney M, McGinity James W, Peppas Nicholas A
机构信息
Department of Chemical Engineering, The University of Texas at Austin, 1 University Station, C0400, Austin, TX 78712-1062, USA.
出版信息
Polymer (Guildf). 2007 Aug 10;48(17):5042-5048. doi: 10.1016/j.polymer.2007.06.035.
Abstract
Smart biomaterials composed of pH responsive polymers, poly((meth)acrylic acid), were synthesized using a precipitation polymerization technique. The microparticles were grafted with poly(ethylene glycol) (PEG) chains that are capable of complexing with the hydroxyl groups of the polyacid and interpenetrating into the mucus gel layer upon entry into the small intestine. Upon introduction of an alkaline solution, these materials imbibe a significant amount of water and create a highly viscous suspension. These materials have the necessary physicochemical properties to serve as mucoadhesive controlled release drug carriers for the oral delivery of drugs.
摘要
采用沉淀聚合法合成了由pH响应聚合物聚（（甲基）丙烯酸）组成的智能生物材料。微粒接枝有聚乙二醇（PEG）链，该链能够与聚酸的羟基络合并在进入小肠后渗透到黏液凝胶层中。引入碱性溶液后，这些材料会吸收大量水分并形成高粘性悬浮液。这些材料具有必要的物理化学性质，可作为用于口服给药的黏膜粘附控释药物载体。
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