吸收与转运对蛋白质治疗药物智能疗法及纳米级递送的影响。
Impact of Absorption and Transport on Intelligent Therapeutics and Nano-scale Delivery of Protein Therapeutic Agents.
作者信息
Peppas Nicholas A, Carr Daniel A
机构信息
Center of Biomaterials, Drug Delivery, Bionanotechnology and Molecular Recognition, Departments of Chemical and Biomedical Engineering and College of Pharmacy, The University of Texas at Austin, 1 University Station C0400, Austin, Texas 78712, USA.
出版信息
Chem Eng Sci. 2009 Nov 16;64(22):4553-4565. doi: 10.1016/j.ces.2009.04.050.
The combination of materials design and advances in nanotechnology has led to the development of new therapeutic protein delivery systems. The pulmonary, nasal, buccal and other routes have been investigated as delivery options for protein therapy, but none result in improved patient compliances and patient quality of life as the oral route. For the oral administration of these new systems, an understanding of protein transport is essential because of the dynamic nature of the gastrointestinal tract and the barriers to transport that exist.Models have been developed to describe the transport between the gastrointestinal lumen and the bloodstream, and laboratory techniques like cell culture provide a means to investigate the absorption and transport of many therapeutic agents. Biomaterials, including stimuli-sensitive complexation hydrogels, have been investigated as promising carriers for oral delivery. However, the need to develop models that accurately predict protein blood concentration as a function of the material structure and properties still exists.
材料设计与纳米技术进步的结合推动了新型治疗性蛋白质递送系统的发展。肺部、鼻腔、口腔及其他给药途径已作为蛋白质治疗的递送选择进行了研究，但没有一种途径能像口服途径那样提高患者的依从性和生活质量。对于这些新系统的口服给药，由于胃肠道的动态性质和存在的转运屏障，了解蛋白质转运至关重要。已经开发出模型来描述胃肠道腔与血液之间的转运，细胞培养等实验室技术提供了一种研究许多治疗剂吸收和转运的方法。包括刺激敏感络合水凝胶在内的生物材料已被研究作为口服递送的有前景的载体。然而，仍然需要开发能够根据材料结构和性质准确预测蛋白质血药浓度的模型。
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