Department of Ophthalmology, Stanford University School of Medicine, Stanford, California 94305, USA.
Stem Cells Dev. 2009 Jan-Feb;18(1):7-16. doi: 10.1089/scd.2008.0169.
The Wnt-signaling pathway is a known regulator of stem cell maintenance, cellular proliferation and differentiation, and cancer development in various tissues. Wnt proteins play a central role during various stages of retinal development; retinal field establishment, retinal and hyaloid vasculogenesis, cornea and lens development, eye field formation, and maintenance of retinal stem cell and neuronal specification in many species are Wnt-regulated processes. Uncontrolled Wnt signaling may cause retinal diseases such as familial exudative vitroretinopathy, retinitis pigmentosa, and Norrie's disease, further underscoring the importance of the Wnt-signaling pathway in the retina. This review summarizes major developments and discoveries regarding the role of the Wnt-signaling pathway as it pertains to retinal development and disease.
Wnt 信号通路是一种已知的干细胞维持、细胞增殖和分化以及各种组织中癌症发展的调节剂。Wnt 蛋白在视网膜发育的各个阶段发挥核心作用；视网膜区域建立、视网膜和玻璃体液血管生成、角膜和晶状体发育、眼区形成以及在许多物种中视网膜干细胞和神经元特化的维持是受 Wnt 调节的过程。Wnt 信号的不受控制可能导致视网膜疾病，如家族性渗出性玻璃体视网膜病变、色素性视网膜炎和 Norrie 病，这进一步强调了 Wnt 信号通路在视网膜中的重要性。本综述总结了 Wnt 信号通路在视网膜发育和疾病中的作用的主要进展和发现。
