Davies Emma C, Green Christophe F, Mottram David R, Pirmohamed Munir
The Royal Liverpool University Hospital Trust, Prescot Street, Liverpool, L7 8XP, UK.
Curr Drug Saf. 2007 Jan;2(1):79-87. doi: 10.2174/157488607779315507.
The serious nature of adverse drug reactions (ADRs) has been highlighted in a number of instances over the last forty years, the most recent of these being the occurrence of serious thrombotic events with the use of COX-2 inhibitors. ADRs are estimated to be between the 4(th) and 6(th) leading cause of death in the USA, with fatal ADRs occurring in 0.32% of patients. A recent UK study showed that 6.5% of hospital admissions were related to ADRs. ADRs can therefore be regarded as a significant public health and economic problem. There is an urgent need to develop better preventive strategies to reduce the burden of ADRs. Because ADRs can affect any bodily system, can have many different clinical presentations, and are of widely variable severity, prevention will not be easy and will have to be multifactorial in its approach. This paper reviews the epidemiology of ADRs in hospitals and evaluates the research that has been undertaken to date to prevent ADRs.
在过去四十年里，药物不良反应（ADR）的严重性在许多情况下都得到了凸显，其中最近的一次是使用COX - 2抑制剂时出现的严重血栓事件。据估计，在美国，ADR是导致死亡的第四至第六大主要原因，0.32%的患者会发生致命性ADR。英国最近的一项研究表明，6.5%的住院病例与ADR有关。因此，ADR可被视为一个重大的公共卫生和经济问题。迫切需要制定更好的预防策略以减轻ADR的负担。由于ADR可影响身体的任何系统，临床表现多种多样，严重程度差异很大，预防并非易事，必须采取多方面的方法。本文综述了医院中ADR的流行病学，并评估了迄今为止为预防ADR所开展的研究。
