MCI 和 AD 患者的全脑萎缩率与 CSF 生物标志物水平：一项纵向研究。
Whole-brain atrophy rate and CSF biomarker levels in MCI and AD: a longitudinal study.
机构信息
Alzheimer Centre and Department of Diagnostic Radiology, VU University Medical Center, Amsterdam, The Netherlands.
出版信息
Neurobiol Aging. 2010 May;31(5):758-64. doi: 10.1016/j.neurobiolaging.2008.06.016. Epub 2008 Aug 8.
OBJECTIVES
To assess associations between cerebrospinal fluid (CSF) biomarker levels and MRI-based whole-brain atrophy rate in mild cognitive impairment (MCI) and Alzheimer's disease (AD).
METHODS
We included 99 patients (47 AD, 29 MCI, 23 controls) who underwent lumbar puncture at baseline and repeat MRI. A subgroup of 48 patients underwent a second lumbar puncture. CSF levels of beta-amyloid(1-42) (A beta(1-42)), tau and tau phosphorylated at threonine-181 (P-tau(181)), and whole-brain atrophy rate were measured.
RESULTS
Across groups, baseline A beta(1-42) and tau were modestly associated with whole-brain atrophy rate. Adjusted for age, sex and diagnosis, we found no association between A beta(1-42) or tau, and whole-brain atrophy rate. By contrast, high CSF levels of P-tau(181) showed a mild association with a lower whole-brain atrophy rate in AD but not in controls or MCI patients. Finally, whole-brain atrophy rate was associated with change in MMSE, but change in CSF biomarker levels was not.
CONCLUSIONS
Whole-brain atrophy rate and CSF levels of A beta(1-42,) tau or P-tau(181) provide complementary information in patients with MCI and AD.
目的
评估脑脊液（CSF）生物标志物水平与轻度认知障碍（MCI）和阿尔茨海默病（AD）患者基于 MRI 的全脑萎缩率之间的关联。
方法
我们纳入了 99 名患者（47 名 AD、29 名 MCI、23 名对照），他们在基线时接受了腰椎穿刺，并进行了重复 MRI。48 名患者接受了第二次腰椎穿刺。测量了脑脊液中β-淀粉样蛋白（1-42）（Aβ（1-42））、tau 和 tau 在苏氨酸-181 处磷酸化（P-tau（181））以及全脑萎缩率。
结果
在所有组中，基线 Aβ（1-42）和 tau 与全脑萎缩率有一定的相关性。在调整年龄、性别和诊断后，我们发现 Aβ（1-42）或 tau 与全脑萎缩率之间没有关联。相比之下，AD 患者的 CSF 中 P-tau（181）水平较高与较低的全脑萎缩率轻度相关，但在对照组或 MCI 患者中则没有。最后，全脑萎缩率与 MMSE 的变化相关，但 CSF 生物标志物水平的变化则不相关。
结论
在 MCI 和 AD 患者中，全脑萎缩率和 CSF 中 Aβ（1-42）、tau 或 P-tau（181）水平提供了互补的信息。
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