French D L, Muir J M, Webber C E
Department of Radiology, McMaster University, Hamilton, Ontario, Canada.
Phytomedicine. 2008 Dec;15(12):1069-78. doi: 10.1016/j.phymed.2008.06.007. Epub 2008 Aug 6.
Identification of natural health products that might benefit skeletal health could reduce the negative impact of osteoporotic bone fractures upon society. The objectives of this study were to evaluate an animal model of postmenopausal osteoporosis and to search for evidence that curcumin reduces bone mineral losses in a dose-dependent manner when endogenous estrogen levels are reduced. Bone mineral density was measured at the spine, femur and whole body before and at 2, 4 and 6 months after ovariectomy in each of 40 mature rats. Serum osteocalcin and C-telopeptide were measured as indicators of bone formation and resorption rates. Femoral compressive strength was measured at 6 months. Ovariectomy alone resulted in loss of mineral from the spine (p<0.005) and an increase in osteocalcin levels (p<0.05). At the same time, there was an increase in energy to fracture (p<0.01) due to an increased bone size. When ovariectomized animals were given etidronate there was no loss of mineral from the spine, the size of the femur increased (p<0.005), C-telopeptide levels were reduced (p<0.001) and femoral compressive strength increased (p<0.025). Administration of curcumin to ovariectomized animals resulted in changes that were intermediate between those produced by etidronate and by ovariectomy alone. The increase in femur size produced by the highest dose of curcumin was statistically significant (p< 0.01) and curcumin administration resulted in a significant, dose dependent, increase in energy to fracture. Curcumin produces beneficial changes in bone turnover and increases in bone strength using the ovariectomized mature rat model of postmenopausal osteoporosis.
识别可能有益于骨骼健康的天然保健品，有助于减轻骨质疏松性骨折对社会造成的负面影响。本研究的目的是评估绝经后骨质疏松症的动物模型，并寻找证据证明当内源性雌激素水平降低时，姜黄素能以剂量依赖的方式减少骨矿物质流失。对40只成年大鼠在卵巢切除术前以及术后2、4和6个月时测量其脊柱、股骨和全身的骨矿物质密度。测量血清骨钙素和C-末端肽，作为骨形成和骨吸收速率的指标。在6个月时测量股骨抗压强度。仅卵巢切除就导致脊柱矿物质流失（p<0.005）以及骨钙素水平升高（p<0.05）。与此同时，由于骨骼尺寸增加，骨折能量增加（p<0.01）。给卵巢切除的动物服用依替膦酸盐后，脊柱没有矿物质流失，股骨尺寸增加（p<0.005），C-末端肽水平降低（p<0.001），股骨抗压强度增加（p<0.025）。给卵巢切除的动物服用姜黄素后产生的变化介于依替膦酸盐和仅卵巢切除所产生的变化之间。最高剂量姜黄素使股骨尺寸增加具有统计学意义（p<0.01），并且服用姜黄素导致骨折能量显著且呈剂量依赖性增加。利用卵巢切除的成年大鼠绝经后骨质疏松症模型，姜黄素在骨转换方面产生了有益变化，并增加了骨强度。
