Basilico N, Bosisio E, Buelli F, Campiani G, Casagrande M, Castelli F, Coghi P, Corbett Y, Cortelezzi L, D'Alessandro S, Dell'Agli M, Esposito F, Fattorusso C, Fattorusso E, Finaurini S, Galli G V, Gemma S, Habluetzel A, Lucantoni L, Melato S, Monti D, Olliaro P, Omodeo-Salè F, Parapini S, Persico M, Rizzi M, Romeo S, Rossi F, Rusconi C, Sparatore A, Scafati O Taglialatela, van den Bogaart E, Taramelli D, Vaiana N, Yerbanga S
Dipartimento Salute Pubblica-Microbiologia-Virologia, Università di Milano, Italy.
Parassitologia. 2008 Jun;50(1-2):133-6.
Clinical treatment-failures to affordable drugs encouraged new investigation for discovery and development of new prophylactic and therapeutic interventions against malaria. The Drug Discovery Cluster (DDcl) of the Italian Malaria Network gathers several highly integrated and complementary laboratories from different Italian Institutions to identify, synthesise, screen in vitro and in vivo new antimalarial molecules directed against the intraerythrocytic stage of P. falciparum parasites and/or with transmission blocking activity to select lead compounds for further development. Complementary research activities, both in vitro and in the clinics, aim at investigating the pathogenetic mechanisms of severe malaria anaemia and the different manifestations of the disease in malaria-HIV co-infected patients to identify new therapies and improve survival.
对平价药物的临床治疗失败促使人们开展新的研究，以发现和开发针对疟疾的新预防和治疗干预措施。意大利疟疾网络的药物发现集群（DDcl）汇聚了来自不同意大利机构的几个高度整合且互补的实验室，以鉴定、合成、进行体外和体内筛选，寻找针对恶性疟原虫红细胞内期的新型抗疟分子和/或具有传播阻断活性的分子，从而选择先导化合物进行进一步开发。体外和临床的互补研究活动旨在研究重症疟疾贫血的发病机制以及疟疾 - 艾滋病毒合并感染患者中该疾病的不同表现，以确定新的治疗方法并提高生存率。
