铁在中枢神经系统表面性铁沉积症中的定位
Iron localization in superficial siderosis of the central nervous system.
作者信息
Kellermier Harry, Wang Guoji, Wiley Clayton
机构信息
Neuropathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
出版信息
Neuropathology. 2009 Apr;29(2):187-95. doi: 10.1111/j.1440-1789.2008.00943.x. Epub 2008 Aug 7.
Abstract
Originally conceived as an uncommon disorder, with the advent of MRI, CNS superficial siderosis has been observed more frequently. We present histologic, histochemical, immunohistochemical, immunofluorescent and ultrastructural evaluation of a 56-year-old woman with superficial siderosis. Iron was concentrated in macrophages, superficial astrocytes and gray matter oligodendroglia deep within the cord. While spatially associated with dystrophic glial and neuronal spheroids, iron did not colocalize with mitochondria. Neurotoxic effects were observed despite selective iron localization only within a variety of non-neuronal cell types.
摘要
中枢神经系统表面铁沉积症最初被认为是一种罕见疾病，随着磁共振成像（MRI）的出现，其被观察到的频率更高。我们展示了对一名患有表面铁沉积症的56岁女性进行的组织学、组织化学、免疫组织化学、免疫荧光和超微结构评估。铁集中在巨噬细胞、浅层星形胶质细胞和脊髓深部的灰质少突胶质细胞中。虽然铁在空间上与营养不良性胶质和神经元球状体相关，但它并不与线粒体共定位。尽管铁仅选择性地定位于多种非神经元细胞类型中，但仍观察到了神经毒性作用。
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