p21和p27的多态性共同导致胰腺癌诊断时年龄提前。
Polymorphisms of p21 and p27 jointly contribute to an earlier age at diagnosis of pancreatic cancer.
作者信息
Chen Jinyun, Killary Ann M, Sen Subrata, Amos Christopher I, Evans Douglas B, Abbruzzese James L, Frazier Marsha L
机构信息
Department of Epidemiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
出版信息
Cancer Lett. 2008 Dec 8;272(1):32-9. doi: 10.1016/j.canlet.2008.06.022. Epub 2008 Aug 9.
p21 and p27, members of the kinase inhibitor protein (KIP) family, bind to cyclin-CDK complexes to inhibit their catalytic activity and induce cell cycle arrest. The purpose of our study was to identify whether the p21 (C-to-A), and p27 (T-to-G) polymorphisms were associated with age at diagnosis of pancreatic cancer, either independently or jointly. Two hundred and five patients with a diagnosis of pancreatic cancer were genotyped for the p21 and p27 polymorphisms. We found patients with the p21 variant genotype (CA/AA) had an earlier age at diagnosis than those with the wild-type genotype (CC) (log-rank, P=0.001; HR=1.89; 95%CI, 1.28-2.78). The p21 and p27 polymorphisms combined had a joint effect on age-associated risk for early diagnosis of pancreatic cancer (log-rank, P=0.004; HR=2.91; 95%CI, 1.49-5.67). Our findings suggest that the p21 polymorphism independently and p21 and p27 polymorphisms jointly contribute to a significantly earlier age at diagnosis of pancreatic cancer.
p21和p27是激酶抑制蛋白（KIP）家族的成员，它们与细胞周期蛋白 - 细胞周期蛋白依赖性激酶（CDK）复合物结合，以抑制其催化活性并诱导细胞周期停滞。我们研究的目的是确定p21（C到A）和p27（T到G）多态性是否独立或共同与胰腺癌诊断时的年龄相关。对205例胰腺癌患者进行了p21和p27多态性的基因分型。我们发现，具有p21变异基因型（CA/AA）的患者诊断时的年龄比具有野生型基因型（CC）的患者更早（对数秩检验，P = 0.001；风险比[HR]=1.89；95%置信区间[CI]，1.28 - 2.78）。p21和p27多态性共同对胰腺癌早期诊断的年龄相关风险有联合作用（对数秩检验，P = 0.004；HR = 2.91；95%CI，1.49 - 5.67）。我们的研究结果表明，p21多态性独立地以及p21和p27多态性共同导致胰腺癌诊断时的年龄显著更早。
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