Section of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy.
Department of Woman and Child Health and Public Health - Public Health Area, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
BMC Cancer. 2021 Jun 2;21(1):660. doi: 10.1186/s12885-021-08335-0.
Head and Neck Cancer (HNC) survivors are at increased risk of developing a second primary cancer (SPC). Along with the environmental risk factors, genetic factors have been associated with a potential increased susceptibility to SPC development. We aim to identify the Single Nucleotide Polymorphisms (SNPs) that contribute to SPC development among HNC survivors through a systematic review and meta-analysis.
We searched PubMed, Scopus and ISI Web of Science for eligible studies published in English until January 31st, 2020. We included studies reporting primary data that evaluated the association between SNPs and SPC risk in HNC patients. Data were pooled in a random-effect meta-analyses, when at least two studies on the same SNP evaluated the same genotype model. Heterogeneity was assessed using the χ2-based Q-statistics and the I statistics. Quality of the included studies was assessed using the Q-Genie tool.
Twenty-one studies, of moderate to good quality, were included in the systematic review. Fifty-one genes were reported across the included studies to have significant associations with an increased SPC risk. Overall, 81 out of 122 investigated SNPs were significantly associated with the SPC risk. Seven studies were included in the meta-analysis, which showed five SNPs associated with an increased risk of SPC: p21C70T, CT + TT (HR = 1.76; 95% CI: 1.28-2.43); FASLG -844C > T, CT + TT (HR = 1.82; 95% CI: 1.35-2.46), P21 C98A, CA + AA (HR = 1.75; 95% CI: 1.28-2.38); FAS -670A > G (HR = 1.84; 95% CI: 1.28-2.66) and GST-M1, Null genotype (HR = 1.54; 95% CI: 1.13-2.10).
The identified SNPs in our systematic review and meta-analysis might serve as potential markers for identification of patients at high risk of developing SPC after primary HNC.
CRD42019135612 .
头颈部癌症（HNC）幸存者发生第二原发癌（SPC）的风险增加。除了环境危险因素外，遗传因素也与 SPC 发展的潜在易感性增加有关。我们旨在通过系统评价和荟萃分析确定导致 HNC 幸存者发生 SPC 的单核苷酸多态性（SNP）。
我们检索了 PubMed、Scopus 和 ISI Web of Science 数据库，以获取截至 2020 年 1 月 31 日发表的英文合格研究。我们纳入了报告原发性数据的研究，这些数据评估了 SNP 与 HNC 患者 SPC 风险之间的关系。当至少有两项针对同一 SNP 的研究评估了相同的基因型模型时，数据将在随机效应荟萃分析中进行汇总。使用基于 χ2 的 Q 统计量和 I 统计量评估异质性。使用 Q-Genie 工具评估纳入研究的质量。
21 项研究纳入了系统评价，其中大部分为中高质量研究。纳入的研究共报道了 51 个与 SPC 风险增加显著相关的基因。总体而言，在 122 个研究的 81 个 SNP 与 SPC 风险显著相关。有 7 项研究纳入荟萃分析，其中 5 个 SNP 与 SPC 风险增加相关：p21C70T，CT+TT（HR=1.76；95%CI：1.28-2.43）；FASLG-844C>T，CT+TT（HR=1.82；95%CI：1.35-2.46），P21C98A，CA+AA（HR=1.75；95%CI：1.28-2.38）；FAS-670A>G（HR=1.84；95%CI：1.28-2.66）和 GST-M1，Null 基因型（HR=1.54；95%CI：1.13-2.10）。
我们的系统评价和荟萃分析中确定的 SNP 可能成为识别 HNC 后发生 SPC 高风险患者的潜在标志物。
PROSPERO 注册号：CRD42019135612。
