用于治疗癌症的吡啶基和噻唑基双酰胺集落刺激因子-1受体（CSF-1R）抑制剂
Pyridyl and thiazolyl bisamide CSF-1R inhibitors for the treatment of cancer.
作者信息
Scott David A, Aquila Brian M, Bebernitz Geraldine A, Cook Donald J, Dakin Les A, Deegan Tracy L, Hattersley Maureen M, Ioannidis Stephanos, Lyne Paul D, Omer Charles A, Ye Minwei, Zheng Xiaolan
机构信息
Cancer Research, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA.
出版信息
Bioorg Med Chem Lett. 2008 Sep 1;18(17):4794-7. doi: 10.1016/j.bmcl.2008.07.093. Epub 2008 Jul 27.
PMID:18694641
Abstract
The bisamide class of kinase inhibitors was identified as being active against CSF-1R. The synthesis and SAR of pyridyl and thiazolyl bisamides are reported, along with the pharmacokinetic properties and in vivo activity of selected examples.
摘要
双酰胺类激酶抑制剂被确定对集落刺激因子1受体（CSF-1R）具有活性。本文报道了吡啶基和噻唑基双酰胺的合成、构效关系，以及所选实例的药代动力学性质和体内活性。
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