3-酰胺-4-苯胺基喹啉类作为新型 CSF-1R 抑制剂。
3-amido-4-anilinocinnolines as a novel class of CSF-1R inhibitor.
机构信息
Cancer Research, AstraZeneca R&D Boston, Waltham, MA 02451, USA.
出版信息
Bioorg Med Chem Lett. 2011 Mar 1;21(5):1382-4. doi: 10.1016/j.bmcl.2011.01.033. Epub 2011 Jan 14.
PMID:21295474
Abstract
3-Amido-4-anilinocinnolines have been identified as potent and highly selective inhibitors of CSF-1R. The synthesis and SAR of these compounds is reported, along with some physical property, pharmacokinetic and kinase selectivity data.
摘要
3-酰胺基-4-苯胺基喹啉已被鉴定为 CSF-1R 的有效且高选择性抑制剂。本文报道了这些化合物的合成和 SAR 研究，以及一些物理性质、药代动力学和激酶选择性数据。
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