Pettitt David J, Lawrence Jean M, Beyer Jennifer, Hillier Teresa A, Liese Angela D, Mayer-Davis Beth, Loots Beth, Imperatore Giuseppina, Liu Lenna, Dolan Lawrence M, Linder Barbara, Dabelea Dana
Sansum Diabetes Research Institute, Santa Barbara, California, USA.
Diabetes Care. 2008 Nov;31(11):2126-30. doi: 10.2337/dc08-0769. Epub 2008 Aug 11.
The purpose of this study was to examine age of diabetes diagnosis in youth who have a parent with diabetes by diabetes type and whether the parent's diabetes was diagnosed before or after the youth's birth.
The cohort comprised SEARCH for Diabetes in Youth Study participants (diabetes diagnosis 2001-2005) with a diabetic parent. SEARCH is a multicenter survey of youth with diabetes diagnosed before age 20 years.
Youth with type 2 diabetes were more likely to have a parent with either type 1 or type 2 diabetes (mother 39.3%; father 21.2%) than youth with type 1 diabetes (5.3 and 6.7%, respectively, P < 0.001 for each). Type 2 diabetes was diagnosed 1.68 years earlier among those exposed to diabetes in utero (n = 174) than among those whose mothers' diabetes was diagnosed later (P = 0.018, controlled for maternal diagnosis age, paternal diabetes, sex, and race/ethnicity). Age at diagnosis of type 1 diabetes for 269 youth with and without in utero exposure did not differ significantly (difference 0.96 year, P = 0.403 after adjustment). Controlled for the father's age of diagnosis, father's diabetes before the child's birth was not associated with age at diagnosis (P = 0.078 for type 1 diabetes; P = 0.140 for type 2 diabetes).
Type 2 diabetes was diagnosed at younger ages among those exposed to hyperglycemia in utero. Among youth with type 1 diabetes, the effect of the intrauterine exposure was not significant when controlled for mother's age of diagnosis. This study helps explain why other studies have found higher age-specific rates of type 2 diabetes among offspring of women with diabetes.
本研究旨在按糖尿病类型，研究父母患有糖尿病的青少年的糖尿病诊断年龄，以及父母的糖尿病是在青少年出生前还是出生后被诊断出来的。
该队列包括青少年糖尿病研究（SEARCH）中患有糖尿病的父母的参与者（2001 - 2005年诊断为糖尿病）。SEARCH是一项针对20岁之前被诊断为糖尿病的青少年的多中心调查。
与1型糖尿病青少年（母亲为5.3%，父亲为6.7%，每种情况P < 0.001）相比，2型糖尿病青少年更有可能有患1型或2型糖尿病的父母（母亲为39.3%；父亲为21.2%）。在子宫内暴露于糖尿病的人群（n = 174）中，2型糖尿病的诊断时间比母亲糖尿病诊断较晚的人群早1.68年（P = 0.018，校正了母亲诊断年龄、父亲糖尿病、性别和种族/族裔）。269名有或没有子宫内暴露的青少年1型糖尿病的诊断年龄没有显著差异（差异为0.96年，调整后P = 0.403）。校正父亲的诊断年龄后，孩子出生前父亲患糖尿病与诊断年龄无关（1型糖尿病P = 0.078；2型糖尿病P = 0.140）。
子宫内暴露于高血糖的人群中，2型糖尿病的诊断年龄较小。在1型糖尿病青少年中，校正母亲的诊断年龄后，子宫内暴露的影响不显著。本研究有助于解释为什么其他研究发现糖尿病女性后代中2型糖尿病的年龄别发病率较高。
