[腹水实验性肿瘤中的细胞外核酸]
[Extracellular nucleic acid in ascitic experimental tumors].
作者信息
Belokhvostov A S, Kozlov A P, Zelenkova N K
出版信息
Vopr Onkol. 1976;22(8):45-9.
PMID:186955
Abstract
By using the phenol method, employed for obtaining RNA, the factor possessing electrophoretic mobility close to that of more rapidly migrating conformomer 5 S p-RNA and resistant to the action of pancreatic RNA-s was isolated from noncellular ascitic fluid, Ehrlich and NK/Ly tumors, hepatoma 22a, Zajdela hepatoma, ovarian ascites tumor in rats. This factor is suggested to participate in suppression of antitumor immunity in cancer.
摘要
通过用于获取RNA的酚法，从大鼠的无细胞腹水、艾氏腹水瘤和NK/Ly肿瘤、肝癌22a、扎伊德氏肝癌、卵巢腹水瘤中分离出一种因子，其电泳迁移率与迁移较快的构象异构体5S p-RNA相近，且对胰RNA酶的作用具有抗性。提示该因子参与癌症中抗肿瘤免疫的抑制。
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