Iwatsuki Koichi, Yoshimine Toshiki, Kishima Haruhiko, Aoki Masanori, Yoshimura Kazuhiro, Ishihara Masahiro, Ohnishi Yuichiro, Lima Carlos
aDepartment of Neurosurgery, Osaka University Medical School, Suita, Osaka, Japan.
Neuroreport. 2008 Aug 27;19(13):1249-52. doi: 10.1097/WNR.0b013e328305b70b.
Several recent studies have demonstrated the potential therapeutic role of olfactory ensheathing cells in spinal cord injury. The aim of this study was to elucidate whether grafts of nasal olfactory mucosa containing olfactory ensheathing cells can repair the injured rat spinal cord as compared with the nasal respiratory mucosa containing no olfactory ensheathing cells. These grafts were then transplanted into the partially removed rat spinal cord. Compared with the respiratory mucosa-transplanted rats, the olfactory mucosa-transplanted rats partially recovered the movement of their hindlimbs and joints. Corticospinal tracing indicated that olfactory mucosa transplantation restored the severed tract. Therefore, olfactory mucosa has potential value in the repair of spinal cord injury.
最近的几项研究已经证明了嗅鞘细胞在脊髓损伤中的潜在治疗作用。本研究的目的是阐明与不含嗅鞘细胞的鼻呼吸黏膜相比，含有嗅鞘细胞的鼻嗅黏膜移植是否能够修复受损的大鼠脊髓。然后将这些移植物移植到部分切除的大鼠脊髓中。与移植了呼吸黏膜的大鼠相比，移植了嗅黏膜的大鼠后肢和关节的运动部分恢复。皮质脊髓束示踪表明，嗅黏膜移植恢复了被切断的神经束。因此，嗅黏膜在脊髓损伤修复中具有潜在价值。
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