Bianco John, De Berdt Pauline, Deumens Ronald, des Rieux Anne
Louvain Drug Research Institute, Advanced Drug Delivery and Biomaterials, Université catholique de Louvain, Avenue Mounier, 73, B1 73.12, 1200, Brussels, Belgium.
Integrated Center for Cell Therapy and Regenerative Medicine, International Clinical Research Center (FNUSA-ICRC), St. Anne's University Hospital Brno, Pekařská 53, 656 91, Brno, Czech Republic.
Cell Mol Life Sci. 2016 Apr;73(7):1413-37. doi: 10.1007/s00018-015-2126-5. Epub 2016 Jan 14.
Dental stem cells are an emerging star on a stage that is already quite populated. Recently, there has been a lot of hype concerning these cells in dental therapies, especially in regenerative endodontics. It is fitting that most research is concentrated on dental regeneration, although other uses for these cells need to be explored in more detail. Being a true mesenchymal stem cell, their capacities could also prove beneficial in areas outside their natural environment. One such field is the central nervous system, and in particular, repairing the injured spinal cord. One of the most formidable challenges in regenerative medicine is to restore function to the injured spinal cord, and as yet, a cure for paralysis remains to be discovered. A variety of approaches have already been tested, with graft-based strategies utilising cells harbouring appropriate properties for neural regeneration showing encouraging results. Here we present a review focusing on properties of dental stem cells that endorse their use in regenerative medicine, with particular emphasis on repairing the damaged spinal cord.
牙干细胞是一个已经相当拥挤的舞台上的一颗新星。最近，在牙科治疗中，尤其是在再生牙髓病学中，人们对这些细胞大肆炒作。大多数研究集中在牙齿再生上是合适的，尽管这些细胞的其他用途需要更详细地探索。作为真正的间充质干细胞，它们的能力在其天然环境之外的领域也可能被证明是有益的。其中一个领域是中枢神经系统，特别是修复受损的脊髓。再生医学中最艰巨的挑战之一是恢复受损脊髓的功能，迄今为止，瘫痪的治愈方法仍有待发现。已经测试了多种方法，利用具有适合神经再生特性的细胞的基于移植的策略显示出令人鼓舞的结果。在这里，我们提出一篇综述，重点关注支持牙干细胞在再生医学中应用的特性，特别强调修复受损脊髓。
