Peluso G, Ambrosio L, Cinquegrani M, Nicolais L, Tajana G
Institute of Protein Biochemistry and Enzymology-CNR, Naples, Italy.
J Biomed Mater Res. 1991 May;25(5):637-49. doi: 10.1002/jbm.820250507.
The activation of cells by interaction with solid surfaces is important in many settings, including the response of tissue to implanted materials. However, few comprehensive studies of both cell migration and activation have been performed so that the connection between these events and immunological activation against foreign material is not well understood. In the present study, synthesis and expression of Ia antigens by peritoneal exudate macrophages after implantation of different carbon fiber composites in the rat peritoneal cavity have been investigated in order to determine whether the type of material implanted affected the composition of Ia-bearing cells of the exudate. The results have confirmed the low level of expression of Ia on resident peritoneal macrophages; while we have found that macrophages, harvested after implantation, express a different amount of Ia related to the different cure cycles of the composite material used.
细胞与固体表面相互作用所引发的激活在许多情况下都很重要，包括组织对植入材料的反应。然而，关于细胞迁移和激活的全面研究却很少，因此这些事件与针对外来物质的免疫激活之间的联系尚未得到充分理解。在本研究中，我们研究了大鼠腹腔内植入不同碳纤维复合材料后，腹腔渗出巨噬细胞Ia抗原的合成与表达，以确定植入材料的类型是否会影响渗出液中携带Ia细胞的组成。结果证实了驻留腹腔巨噬细胞上Ia的低表达水平；同时我们发现，植入后收获的巨噬细胞表达的Ia量与所用复合材料的不同固化周期有关。
