Manger B
Medizinische Klinik III, Klinikum der Friedrich-Alexander-Universität, Krankenhausstr. 12, 91054, Erlangen, Deutschland.
Z Rheumatol. 2008 Sep;67(5):415-22; quiz 423. doi: 10.1007/s00393-008-0325-2.
Adult onset Still's disease is a rare, febrile, multisystem rheumatic disease with unknown etiology, which runs an intermittent course and can either go into remission after months to years or progress to a chronic course with substantial joint destruction. The prevalence of this disease has been increasing in the last decade presumably caused by better diagnostic tools but also by a higher awareness among physicians taking care of patients with "fever of unknown origin". This review is intended to augment this trend, since research on the role of proinflammatory cytokines in this disease has led to an improved diagnostic and therapeutic repertoire over the last few years. Ferritin and interleukin-18 serum levels are valuable diagnostic parameters and blockade of interleukin-1, interleukin-6, and tumor-necrosis-factor alpha can effectively control the inflammatory activity of this disease in most cases and also in life-threatening conditions.
成人斯蒂尔病是一种罕见的、发热性的多系统风湿性疾病，病因不明，呈间歇性病程，数月至数年后可缓解，或进展为伴有严重关节破坏的慢性病程。在过去十年中，这种疾病的患病率一直在上升，这可能是由于诊断工具的改进，也由于诊治“不明原因发热”患者的医生意识提高。本综述旨在强化这一趋势，因为过去几年对促炎细胞因子在该疾病中作用的研究带来了更好的诊断和治疗方法。铁蛋白和白细胞介素-18血清水平是有价值的诊断参数，在大多数情况下，阻断白细胞介素-1、白细胞介素-6和肿瘤坏死因子α可有效控制该疾病的炎症活动，在危及生命的情况下也是如此。
