Shook B L, Schlag-Rey M, Schlag J
Department of Anatomy and Cell Biology, UCLA School of Medicine.
J Comp Neurol. 1991 May 22;307(4):562-83. doi: 10.1002/cne.903070405.
The supplementary eye field (SEF) was defined electrophysiologically in behaving monkeys to study its connections with the diencephalon and corpus striatum. The specificity of SEF pathways was determined with horseradish peroxidase (HRP) histochemistry to compare its connections with those of the arcuate frontal eye field (FEF), contiguous dorsocaudal area 6 (6DC), and primary motor cortex (M1, arm/hand region). Results indicate that patterns of SEF connectivity were similar to the FEF and markedly different from areas 6DC and M1. Primary reciprocal thalamic pathways of the SEF were with the magnocellular ventral anterior (VA) nucleus, medial parvicellular VA, medial area X, and paralaminar medialis dorsalis (multiformis and parvicellularis). FEF showed similar connections but its most robust pathway was with MD rather than VA. In contrast, area 6DC showed the most extensive reciprocal connections with lateral VApc and lateral area X with only sparse connections with paralaminar MD. Area 6DC also exhibited reciprocal connections with the ventral lateral (VL) complex and the ventral posterior lateral nucleus, pars oralis (VPLo). M1 showed dense bidirectional connections with VPLo, and to a lesser extent, with VL. M1 pathways with the medial dorsal nucleus were negligible. All areas exhibited connections with the paracentral and central lateral nuclei and only M1 lacked connections with the central superior lateral nucleus. SEF and FEF exhibited similar efferent projections to the caudate and putamen. In the caudate, terminal fields were restricted to a central longitudinal core while those from area 6DC were more widely distributed. Eye field efferents were restricted to the putamen's face region while 6DC projections were more exuberant. The arm/hand region of M1 projected to the arm/hand region of the putamen. Pathways are discussed with respect to their significance in oculomotor control.
在行为学实验的猴子中，通过电生理学方法定义了辅助眼区（SEF），以研究其与间脑和纹状体的连接。利用辣根过氧化物酶（HRP）组织化学方法确定了SEF通路的特异性，以比较其与弓形额叶眼区（FEF）、相邻的背尾侧6区（6DC）和初级运动皮层（M1，手臂/手部区域）的连接。结果表明，SEF的连接模式与FEF相似，与6DC和M1区域明显不同。SEF的主要丘脑相互连接通路是与大细胞腹前（VA）核、内侧小细胞VA、内侧X区和旁层背内侧（多形和小细胞）。FEF显示出类似的连接，但最强大的通路是与背内侧核而非VA。相比之下，6DC区与外侧VApc和外侧X区的相互连接最为广泛，与旁层背内侧的连接稀疏。6DC区还与腹外侧（VL）复合体和腹后外侧核口部（VPLo）表现出相互连接。M1与VPLo表现出密集的双向连接，与VL的连接程度较轻。M1与背内侧核的通路可忽略不计。所有区域都与中央旁核和中央外侧核有连接，只有M1与中央上外侧核没有连接。SEF和FEF对尾状核和壳核表现出类似的传出投射。在尾状核中，终末场局限于中央纵向核心，而来自6DC区的终末场分布更广泛。眼区传出纤维局限于壳核的面部区域，而6DC区的投射更丰富。M1的手臂/手部区域投射到壳核的手臂/手部区域。讨论了这些通路在眼球运动控制中的意义。
